Advertisement

Sign up for our daily newsletter

Advertisement

Hypothyroidism vs hyperthyroidism causes hyponatremia – Hyponatremia and the Thyroid: Causality or Association?

The effect of inappropriate antidiuretic hormone in the setting of hypothyroidism was studied and refuted by many studies [10,11,14]. You also tire easily with exercise.

Matthew Cox
Monday, October 12, 2020
Advertisement
  • Support Center Support Center. Patients with possible hyponatremic encephalopathy should be urgently treated according to current guidelines.

  • In the absence of reduced GFR, hypothyroidism would not be expected to cause reduction in serum Na.

  • Severe hypothyroidism is often associated with hyponatraemia.

  • Submit a Manuscript.

Article Alerts

Article Google Scholar Main article text. ADH measurement confirmed the diagnostic suspicion of SIADH with the patient responding very well to thyroid replacement and fluid restriction.

When rats were treated chronically with either propylthiouracil or thiouracil, they developed a negative sodium balance, lost weight causes hyponatremia eventually died if given a diet deficient in sodium long enough [15]. A cohort of patients with differentiated thyroid cancer admitted for radioiodine treatment was prospectively studied. Chest X-ray normal. Sameera Daud for helping with the design of the study. Absence of relation between hyponatraemia and hypothyroidism. ISSN: The values were then combined to include the closest two measures of sodium and TSH.

When moderate to severe hyponatremia is encountered, concomitant etiologies of hyponatremia should be sought in addition to hypothyroidism. Severe hypothyroidism is often associated with hyponatraemia. The remedy to this confusion lies in understanding the pathophysiology of the real impact of hypothyroidism on serum Na concentration. Full size image.

Article Alerts

Publication types Review. Changes in renal function in primary hypothyroidism. Study population Patients who had both serum sodium Na and serum thyrotropin TSH obtained previously were included in the study.

Others at higher risk include a child or elderly person with a lump nodule in the thyroid. A mild to moderate decrease in serum sodium may be expected only when hypothyroidism vs hyperthyroidism causes hyponatremia of prolonged severe hypothyroidism develop such as peripheral edema, reduced GFR, and changed mental status as seen in MC. Acta Paediatrica,93 1 All patients who were seen between September 1, and August 31, in Cleveland Clinic hospitals and out-patient clinics who had serum sodium and TSH. However, it usually produces no symptoms and is discovered incidentally by you or your physician. Croal et al. Some people who are still symptomatic on thyroxine replacement medications may be given T3 replacement hormones in addition to T4 replacement therapy.

In other words, as hypothyroidism worsened serum Na level did not decrease accordingly. Article Sources. Iodine's Role in Thyroid Health. A very small negative correlation was found between increasing TSH and blood sodium levels r: The values were then combined to include the closest two measures of sodium and TSH. View Similar Articles.

Hypothyroidism and Hyponatremia Relationship

More than autoimmune diseases have been identified. Patients with the disease become very sick and have a high fever. Baajafer et al. Hyperthyroidism overactive.

Hyperhhyroidism were plotted and normality was assessed graphically, since, given the sample size, normality tests would likely be overly sensitive to departures from normality. Reduced GFR results in water retention and increased renal sodium excretion by decreasing sodium and net volume delivery to the distal diluting segment of the nephron [10,12]. However, given the shape of the distributions, nonparametric methods were used. American Journal of Kidney Diseases Its frequency depends on multiple factors including the definition of hyponatremia, the frequency of testing, the healthcare setting, and the patient population [1]. Hypothyroidism underactive.

  • J Clin Med. The mechanism of hyponatraemia in hypothyroidism is not fully understood.

  • Islander 0.

  • Conflicts of Interest The authors declare no conflict of interest.

  • Sodium is extremely important for our body for regulating fluid balance, blood pressure, and for normal functioning of the nervous system. These medications include:.

If hypothyroidism remains untreated or undertreated, it may lead to some unpleasant complications:. We have shown that the effect of hypothyroidism vs hyperthyroidism causes hyponatremia on serum Na level was rather very small even in severe hypothyroidism. When optimum serum sodium levels in the body are altered, it affects blood pressure, heart rate, respiratory rate, and body temperature. We are indebted to Dr. When any part of this system is damaged or malfunctioning, the thyroid can produce either too little or too much T3 and T4. Acute thyroiditis is a medical emergency and must be treated with antibiotics and surgery.

The mean TSH value was 2. Keeping these in mind a subgroup analysis was performed for ambulatory patients and in-patients and no significant difference was found. This can cause body-wide symptoms. At that time, doctors thought the x-rays were safe. Hyponatremia and hypothyroidism commonly coexist because both conditions are common.

Publication types

The mean Na value in the entire patient population was However, we have not confirmed their compliance by measuring urine or serum iodine concentrations. J Hosp Med 6: E Browse other volumes. Four nephrology myths debunked.

Published : 31 July We report a case of severe hypothyroidism causing profound hyponatraemia by inappropriate secretion of ADH. Nevertheless, this study does not totally refute the relationship between hypothyroidism and serum Hyponatremis level. Schutt-Aine J. We conclude that in the setting of acute severe hypothyroidism: 1 clinically-important hyponatremia is uncommon; sodium concentration may not need to be monitored unless patients have impaired renal function or are on diuretics, 2 age and female gender are associated with lower sodium concentration. Croal B. Thyroid cancer patients undergoing radioiodine treatment represent a useful model to investigate the effect of acute hypothyroidism on sodium metabolism.

Another subgroup analysis was then performed according to the TSH category to determine whether changes in sodium levels correlated with hypothyroid status. You also tire easily with exercise. Two of these hormones, triiodothyronine T3 and thyroxine T4regulate your metabolism, help your heart, brain, and other organs function, and have a major impact on almost every cell in your body. Each has different causes, symptoms, and treatment.

MeSH terms

Diagnosis is generally via blood and hyyperthyroidism tests. In order to do this, hyperthyroidism causes hyponatremia examined the prevalence of the coexistence of hyponatremia and hypothyroidism as well as the magnitude of the correlation. On the other hand, when you have an overactive thyroid and it produces too much hormone, you have hyperthyroidism. For example, none of the patients with severe hypothyroidism had severe hyponatremia and only very few patients had moderate hyponatremia compared to the majority of patients who had a normal serum Na level for the same high TSH level.

You can end up with diarrhea or frequent bowel movements. Symptoms of hypothyroidism include extreme bradycardia, hypo-tension and delayed relaxation of deep tendon reflexes amongst many others. American Journal of Medicine Updated April 12, In another study, reduced aldosterone was thought to be related to exaggerate Na excretion [18]. Myxedema coma is treated with T4, possibly T3, and some combination of:. Iodine is an element your body can't make on its own, so you depend on food to get enough of it.

Sameera Daud for helping with the design of the study. This can cause body-wide symptoms. A thyroid nodule might cause your voice to become hoarse, or it could make breathing or swallowing difficult. The thyroid is regulated by the pituitary gland in the brain.

Anyone can get thyroid cancer. Clinical Endocrinology Oxf Hyperthytoidism iodine levels can lead to hypothyroidism, and excess iodine in your blood can lead to hypothyroidism or hyperthyroidism. The expected decrease in serum sodium level in severe and prolonged hypothyroidism can be explained by reduced cardiac output increased peripheral resistance, and reduced volume delivery to the kidneys causing a decline in glomerular filtration rate GFR.

About this hypothyroidsm Cite this article Hammami, M. Severe hypothyroidism is often associated with hyponatraemia. Upon admission, patients were asked to keep track and record their fluid intake. Article PubMed Google Scholar. The mean Na value in the entire patient population was Few case report studies [ 12 — 14 ] have addressed hyponatremia in the setting of acute hypothyroidism and radioiodine treatment that typically involve low salt diet and excess fluid intake and possibly anxiety and nausea.

When this disease occurs after pregnancy, it is called postpartum thyroiditis. Hypothyroidism also can cause erectile dysfunction, difficulty ejaculatingand a decreased sex drive. We are indebted to Dr. American Journal of Medicine S Hyponatremia has an extensive list of etiologies including hypothyroidism which has been a common teaching point in text books and review articles to date [2,3]. Limitations of our study can be listed as follows: limitations inherent to retrospective study design, lack of T4 value on most patients, inability to exclude patients who were already on treatment for hypothyroidism and patients who were acutely unwell in which the low or raised TSH values could have been the result of non-thyroidal illnesses or recovery from it, respectively.

Keeping these in mind a subgroup analysis was performed for ambulatory patients and in-patients and no significant difference was found. If a man has a thyroid nodule, it is more likely to be cancerous than if a woman has one. This was investigated both in humans and animal studies [15,16]. It may run in families.

  • In preparation for radioiodine therapy, thyroid hormone treatment is typically withheld and patients are instructed to follow low iodine diet [ 10 ].

  • These drugs may be taken before radioactive iodine or surgery for people with nodules. Related Articles.

  • All analyses were performed using SAS software version 9. Article PubMed Google Scholar

  • Allon M.

  • Serum sodium and creatinine concentrations were determined on Roche Modular Analytics p Download PDF.

Spearman correlation estimates were developed for raw and categorized variables. Toggle navigation. Hypothyroidism and hyperthyroidism are common diseases. At that time, doctors thought the x-rays were safe. However, one group in particular has a higher risk: people who have had radiation to the head or neck. Croal et al.

Edited by: Basow DS. Nevertheless, this jypothyroidism does not totally refute the relationship between hypothyroidism and serum Na level. All ten patients were placed on a low-iodine diet the duration and severity of the dietary restrictions varied. All authors critically reviewed the draft and read and approved the final manuscript. American Family Physician

Background

DOI: Patients suffering hypothyroidism vs hyperthyroidism causes hyponatremia only mild hyponatremia can usually be cured by simply altering diet and lifestyle. Hyponatremia was defined as serum Na Table 1: Categories of thyroid status and sodium status. Hypothyroidism underactive. While each condition has different symptoms and complications that can interfere with your quality of life and a few that are potentially life-threatening, most people with thyroid disease can manage their condition with current medications or medical procedures.

After any of those treatments, it's possible for the hyperthyroidism to return. Toggle navigation. Marks et al. The serum Na concentration before treatment How common is thyroid cancer? Causes and Risk Factors of Thyroid Disease. This coexistence, however, may not necessarily be causal.

ALSO READ: Total Body Slimming Workout Blogilates Meal Plan

Correlations were analyzed using Pearson hpyonatremia test. In the management of patients with differentiated thyroid cancer papillary and follicularsurgery is the primary therapy [ 7 ] and radioiodine is used for ablation of residual thyroid tissue [ 8 ] as well as in the treatment of residual tumor and metastatic disease [ 9 ]. Quick Enquiry. Thyroid function and serum electrolytes: Does an association really exist? Correlations in inpatients and outpatients were However, we have previously reported that in the setting of thyroid hormone therapy withdrawal in patients with differentiated thyroid cancer, only 3. Patient demographics are described in table 2.

Hyperthyrkidism Review reports. Patients of all ages and both genders were included. Metrics details. Conclusions In conclusion, in more recent years, the paradigm that routine cases of hypothyroidism cause hyponatremia has been challenged [ 2122 ]. A very small negative correlation was found between increasing TSH and blood sodium levels r: Hypothyroid myxedema and hyponatremia in an eight-year-old child: A case report.

Patients with the disease become very sick and have a high fever. The Role of Iodine Iodine is an element your body can't make on its own, hypomatremia you depend on food to get enough of it. Article Sources. About 1 million Americans received the treatment, and some of these people will get thyroid cancer up to 40 or more years after receiving the treatment. Nevertheless, this study does not totally refute the relationship between hypothyroidism and serum Na level. When sodium levels fall, brain cells swell up causing a cerebral oedema.

BiosciAbstracts

This gland produces a hormone called thyroid-stimulating hormone TSH to tell the thyroid to make more T3 and T4. J Am Soc Nephrol 1: For every patient, only the first sodium and first TSH were included.

Hyperthyoridism BD: Hyponatremia in hypothyroidism. Aggressive fluid restriction was continued. WH co-conceived of the study and participated in its design and coordination. Article Google Scholar Author affiliations. Reduced cortisol levels also have also been shown to affect serum Na level by inducing ADH secretion [19] and this is a serious consideration in the differential diagnosis of hyponatremia in the presence of hypothyroidism. This review will focus on the thyroid and its association with serum hyponatremia, and review the available literature on the topic.

Results Mean SD age was Hypothyroidism is one of hypothyroidosm causes of hyponatremia, thus thyroid-stimulating hormone determination is mandatory during the evaluation of patients with reduced serum sodium levels. Upon admission, patients were asked to keep track and record their fluid intake. The main endpoint measures were sodium concentrations before admission and at discharge. In the absence of reduced GFR, hypothyroidism would not be expected to cause reduction in serum Na. Materials and Methods We performed a retrospective chart review of patients presenting to either the ambulatory clinics or in-patient units between September 1, and August 31, Four nephrology myths debunked.

This is an open-access hyponattremia distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hypothyroidism and hyperthyroidism are common diseases. Treatment with radioactive iodine is extremely common. Major complications are rare but can include:. There are more than autoimmune diseases.

Hyponatremia is a condition that occurs hypothyroidism vs hyperthyroidism causes hyponatremia sodium levels in our blood drop below a certain level. Table 2: Patient characteristics. National Library of Medicine: MedlinePlus. These drugs may be taken before radioactive iodine or surgery for people with nodules. However, one group in particular has a higher risk: people who have had radiation to the head or neck. Some people worry that the radiation may cause cancer, but the treatment hasn't been linked to increased cancer rates.

The main mechanism for the development of hyponatremia in patients with chronic hypothyroidism is the decreased capacity of free water excretion due to elevated antidiuretic hormone hyperthyrojdism, which are mainly attributed to the hypothyroidism-induced decrease in cardiac output. Since hyponatremia did not occur in our patients despite increased water intake, it appears that the first mechanism may not be implicated in acute hypothyroidism. Ann Pharmacother. Intra-assay CV range was between 0. Patients with possible hyponatremic encephalopathy should be urgently treated according to current guidelines.

Quick Enquiry. In conclusion, in more recent years, the paradigm that routine cases of hypothyroidism cause hyponatremia has been challenged [ 2122 ]. American Journal of Medicine Case report: A year-old lady presented with a 2-week history of confusion and lethargy. Submit a Manuscript.

  • My recently viewed abstracts.

  • Longer duration of salt restriction may have caused a larger change in Na.

  • Asami T. The low prevalence of hyponatremia in that retrospective study may have been due to the fact that sodium concentrations were only determined pre-isolation for radioiodine treatment.

  • Patient demographics are described in table 2. The most common form papillary cancer moves very slowly, and treatment is almost always successful when the cancer is detected early.

  • Pearson chi-square tests were used to measure association between dichotomized values.

You can end up with diarrhea or frequent bowel movements. Categories for TSH casues serum Na level levels were arbitrarily defined as in table 1. However, it usually produces no symptoms and is discovered incidentally by you or your physician. Background: Hypothyroidism has been classically considered as a cause of hyponatremia. How Hypothyroidism Is Treated. Autoimmunity is a malfunction of the immune system.

Hypothyroid myxedema and hyponatremia in an eight-year-old child: A case report. The mean TSH value was 2. Journal of the American Society of Nephrology The association between clinically-important hyponatremia and hypothyroidism may be restricted to chronic uncorrected hypothyroidism. Mean pre-isolation sodium concentration was Toggle navigation.

1. Introduction

Article Alerts Subscribe to our articles alerts and stay tuned. Hyponatremia was defined as serum Na Table 1: Categories of thyroid status and sodium status. Acute thyroiditis A rare disease, is caused by an acute infection. Hyponatremia is most commonly observed in hospitalized patients. American Journal of Medicine S

Updated April 12, However, since thyroid hormones regulate your metabolism, both conditions can affect many parts of your body. American Journal of Medicine S Despite all the elegant descriptions of the pathophysiology of serum Na level changes in hypothyroidism, these reported changes were not at all clinically significant. Sodium is extremely important for our body for regulating fluid balance, blood pressure, and for normal functioning of the nervous system. Acta Paediatrica,93 1 We chose to use TSH as an index of hypothyroidism because it is accepted to be the most sensitive marker of thyroid function in the majority of cases.

ALSO READ: Primary Hypothyroidism Diagnosis Algorithm

Hypohtyroidism the current study we aimed to shed light on the association between hypothyroidism and hyponatremia in a large cohort of patients. Intra-assay Coefficient of variance CV range was between 1. Two of these hormones, triiodothyronine T3 and thyroxine T4regulate your metabolism, help your heart, brain, and other causse function, and have a major impact on almost every cell in your body. The mean sodium value in each TSH category is listed in table 6. Although hyponatremia is known to cause hypothyroidismscientists have so far failed to identify any clear and concrete relation between hypothyroidism and hyponatremia and thus the mechanism is largely not currently understood. Since, we only compared TSH and sodium values, we could have potentially missed patients with central hypothyroidism but those are generally rare. In order to do this, we examined the prevalence of the coexistence of hyponatremia and hypothyroidism as well as the magnitude of the correlation.

Diagnosis, evaluation, and treatment of hyponatremia: Expert panel recommendations. Learn More. Introduction Alteration in thyroid function, particularly the development of hypothyroidism, has historically been linked to the development hypothyroidism vs hyperthyroidism causes hyponatremia serum hyponatremia. In the current study we aimed to shed light on the association between hypothyroidism and hyponatremia in a large cohort of patients. Comparison of pre- post-isolation drop in sodium concentration between acutely hypothyroid males and females undergoing radioiodine treatment. Neth J Med. This is consistent with some [ 1516 ] but not all [ 17 ] of the literature showing a preference of hyponatremia for female gender and gender related differences in antidiuretic response to desmopressin [ 18 ] that may be related to increased expression of vasopressin V2 receptor in females [ 19 ].

The prevalence of the coexistence of hyponatremia and hypothyroidism as well as the magnitude of the correlation were investigated. Toggle navigation. None had brain metastases. Similar percentages were observed in the groups defined by patient status. ADH measurement confirmed the diagnostic suspicion of SIADH with the patient responding very well to thyroid replacement and fluid restriction. Pantalone and Betul A.

In these studies in which reduction in serum sodium was documented, reduced GFR was reported as well. We performed a retrospective chart review of patients presenting to either the ambulatory clinics or in-patient units between September 1, and August 31, In the current study we aimed to shed light on the association between hypothyroidism and hyponatremia in a large cohort of patients.

ADH measurement confirmed the diagnostic suspicion of SIADH with the patient responding very well to thyroid replacement and fluid restriction. Quick Enquiry. American Journal of Kidney Diseases Author and article information.

For example, none of the patients with severe hypothyroidism had severe hyponatremia and only very few patients had moderate hyponatremia compared to the majority of patients who had a normal serum Na level for the same high TSH level. Al Nozha O. There are ten reported cases in the literature of subjects that have developed hyponatremia while undergoing treatment for differentiated thyroid cancer [ 1617181920 ]. Comment: Physicians should be aware of the importance of checking thyroid function tests, when there is unexplained reduction in serum sodium concentration.

Hypothyroidism and hyponatraemia: diagnostic relevance of ADH measurement

Sodium is extremely important for our body for regulating fluid balance, blood pressure, and for normal functioning of the nervous system. How Hypothyroidism Is Treated. Subacute thyroiditis is painful, causing a tender, swollen thyroid gland with pain throughout the neck.

Summary Programme Abstracts. Thyroid disorders, particularly hypothyroidism, have historically been implicated in the development hyperthyroodism serum hyponatremia. Recently the strength of this association was disputed by a few number of smaller studies [4,5]. Data were plotted and normality was assessed graphically, since, given the sample size, normality tests would likely be overly sensitive to departures from normality. Hawkins RC: Age and gender as risk factors for hyponatremia and hypernatremia. Severe hyponatremia: A danger of low-iodine diet.

  • Hypothyroidism as a cause of hyponatremia: Fact or fiction?

  • American Family Physician

  • Background Hypothyroidism is a text-book cause of hyponatremia [ 1 ]. Correlations were analyzed using Pearson r test.

Lancet This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Hypothyroidism underactive. Each has different causes, symptoms, and treatment.

Am J Med. American Journal of Kidney Diseases J Clin Med. Conclusions In conclusion, in more recent years, the paradigm that routine cases of hypothyroidism cause hyponatremia has been challenged [ 2122 ]. In this study we were able to show a very weak association between hyponatremia and hypothyroidism in the largest cohort of patients studied to date.

Publication types

Hypothyroidism as a cauees of hyponatremia: Fact or fiction? Table 6: Serum sodium by thyroid state. In addition, we have identified the following risk factors for hypothyroidism associated lowering of sodium concentration, age, elevated creatinine concentration, and diuretics use. Case report: A year-old lady presented with a 2-week history of confusion and lethargy. More recently, Sun et al.

Long-standing severe hypothyroidism, especially in older patients, can cause Myxedema coma. Study population Patients who had both serum sodium Na and serum thyrotropin TSH obtained previously were included in the study. American Thyroid Association. ISSN:

  • Diagnosis, evaluation, and treatment of hyponatremia: Expert panel recommendations.

  • When sodium levels fall, brain cells swell up causing a cerebral oedema. Its frequency depends on multiple factors including the definition of hyponatremia, the frequency of testing, the healthcare setting, and the patient population [1].

  • The values were then combined to include the closest two measures of sodium and TSH.

  • Four nephrology myths debunked.

Thyroid disorders, particularly hypothyroidism, have historically been implicated in the development of serum hyponatremia. In addition, for patients who developed post-isolation hyponatremia, sodium concentrations while on thyroxine treatment documented by suppressed TSH were recorded when available. Aggressive fluid restriction was continued. Contact us Submission enquiries: bmcendocrinedisorders biomedcentral. When rats were treated chronically with either propylthiouracil or thiouracil, they developed a negative sodium balance, lost weight and eventually died if given a diet deficient in sodium long enough [15]. Nevertheless, this study does not totally refute the relationship between hypothyroidism and serum Na level.

Sign up and get yours free! When it fails to do this correctly, and water levels in the hypothyroidism vs hyperthyroidism causes hyponatremia get too high, the resulting causew in sodium concentration causes hyponatremia. For every patient, only the first sodium and first TSH were included. Hyperactive thyroid has fewer potential causes. Islander 0. Low iodine levels can lead to hypothyroidism, and excess iodine in your blood can lead to hypothyroidism or hyperthyroidism. Main article text.

Severe hypothyroidism is often associated with hyponatraemia. Hammami, M. Article Google Scholar View author publications. Changes in aldosterone levels were reversed by treatment with thyroxine.

Over time, the disease destroys thyroid tissue until permanent hypothyroidism results. Since, we only compared TSH and sodium values, we could have potentially missed patients with central hypothyroidism hyponatrejia those are generally rare. The correlation estimate r being a hypertthyroidism small number indicates that this was an artifact of the large sample size and the association between serum Na level and TSH was clinically negligible in both inpatients and outpatients. Your blood flow, water retention, and cellular replacement may decrease as well, affecting the health of your skin, hair, and nails. We chose to use TSH as an index of hypothyroidism because it is accepted to be the most sensitive marker of thyroid function in the majority of cases. While hypothyroidism can't be cured, it can be managed with the appropriate treatment. Some people who are still symptomatic on thyroxine replacement medications may be given T3 replacement hormones in addition to T4 replacement therapy.

Author and article information. Warner M. In contrast, Montenegro et al. Summary Programme Abstracts. Rachoin J. View Similar Articles.

Major complications are rare but can include:. Hypothyroidism underactive. It may run in families. Radioactive iodinetaken by mouth, damages or destroys thyroid cells, thereby leaving fewer cells to produce thyroid hormones and shrinking nodules. Updated April 12,

Beta-blockers won't hypothyroidism vs hyperthyroidism causes hyponatremia your thyroid hormone levels, but they can block the actions of the hormones hpothyroidism alleviate symptoms. Hyponatremia is the most common electrolyte abnormality encountered in ambulatory and hospital settings. The serum Na concentration before treatment Symptoms of hypothyroidism include extreme bradycardia, hypo-tension and delayed relaxation of deep tendon reflexes amongst many others. We have shown that the effect of hypothyroidism on serum Na level was rather very small even in severe hypothyroidism.

However, given the shape of the distributions, nonparametric methods were used. Materials and Hyperthyroididm We performed a retrospective chart review of patients presenting to either the ambulatory clinics or in-patient units between September 1, and August 31, When published studies are carefully reviewed, it is clear that MC is generally not associated with severe serum Na changes. Acute thyroiditis is a medical emergency and must be treated with antibiotics and surgery.

ALSO READ: Type 2 Diabetes Mellitus And Hypothyroidism The Possible Influence Of Metformin Therapy

Lewis S. Low aldosterone levels in hypothyroid patients were demonstrated in a hyporhyroidism studies [17,18] albeit clinical merit in these studies were rather small. Materials and Methods We performed a retrospective chart review of patients presenting to either the ambulatory clinics or in-patient units between September 1, and August 31, We performed a retrospective chart review of patients presenting to either the ambulatory clinics or in-patient units between September 1, and August 31, Table 3: Univariable summaries of TSH and sodium overall and within patient status. Figure 2. Introduction Alteration in thyroid function, particularly the development of hypothyroidism, has historically been linked to the development of serum hyponatremia.

  • Journal of Endocrinological Investigation

  • Your face and hands may appear puffy.

  • References 1.

  • Edited by: Basow DS.

Peer Review reports. The low prevalence of hyponatremia in that retrospective study may have been due to the fact that sodium concentrations were only determined pre-isolation for radioiodine treatment. The strength of this study is that it is the largest reported cohort of patients looking at the association of serum Na and TSH. Support Center Support Center.

We thank Mr Muajeb AlZahrani for excellent clerical help. However, given the shape of the distributions, nonparametric methods were used. A cohort of patients with differentiated thyroid cancer admitted for radioiodine treatment was prospectively studied. Low aldosterone levels in hypothyroid patients were demonstrated in a few studies [17,18] albeit clinical merit in these studies were rather small. Clin Chim Acta. Methods A cohort of patients with differentiated thyroid cancer admitted for radioiodine treatment was prospectively studied.

J Hosp Med 6: E ISSN: Nevertheless, since no patient in these studies had hyponatremia one can infer that the renin-aldosterone system is not a predominant regulator of serum Na level.

American Thyroid Association. Myxedema coma is treated with T4, possibly T3, and some combination of:. Other causes include:. Article Alerts Subscribe to our articles alerts and stay tuned.

This article has been cited by other articles in PMC. Am J Med. When related publications were carefully reviewed one would notice that many times hypothyroidism was used interchangeably with myxedema or long complicated hypothyroidism. All analyses were performed using SAS software version 9. Subgroups were compared using unpaired t test for continuous variables and Fisher exact test for categorical variables.

Sidebar1?
Sidebar2?