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Naringenin and adiposity – Naringenin Increases Insulin Sensitivity and Metabolic Rate: A Case Study

The addition of naringenin to the diet 1 decreased body weight, fasting glucose and insulin, 2 reduced body fat and perigonadal adipose tissue inflammation, 3 decreased plasma cholesterol and ectopic lipid accumulation in liver and muscle, and 4 affected expression of hepatic genes involved in de novo lipogenesis and fatty acid oxidation. Adv Nutr , 5: —

Matthew Cox
Tuesday, November 10, 2020
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  • The hepatoprotective nature of naringin in a high-fat-diet—fed rat model was partially mediated by activating the AMPK, which restored the antioxidant enzymes and prevented inflammation

  • About this article. Estrogen deficiency has been connected to hepatic fat accumulation in women and rodents [ 326 ].

  • Dietary polyphenols and obesity. It was also reported that a single dose of naringenin and naringin, administered to rats via an i.

  • Dietary naringenin attenuated hyperglycemia and hyperinsulinemia induced by a high-fat or a fructose-enriched diet [ 1233 ]. Additional information Competing interests The authors declare that they have no competing interests.

Introduction

Kennedy Endowment M. Skip to main content. Search all BMC articles Search. Int J Obes Lond— Carr MC: The emergence of the metabolic syndrome with menopause.

Previous studies indicate adipose tissues inflammation occurred early in OVX mice e. Caloric intake decreased significantly when mice were switched to a naringenin-containing diet at week 12 Figure 1 A naringenin and adiposity complete anr to baseline in the following weeks. All authors read, wrote sections of the manuscript, and approved the final manuscript. Abstract Objective: Adverse metabolic changes associated with loss of ovarian function increase the risk of developing metabolic syndrome and non-alcoholic fatty liver disease NAFLD in postmenopausal women. J Lipid Res— However, the effects of naringenin on adipose depot mass and metabolic abnormalities associated with estrogen deficiency have not been studied.

Theoretically, naringenin being polyphenolic and high in electrons can inhibit cytochrome Adiposity enzymes and enhance the bioavailability of medications, including statins. Having observed reduced lipid content in skeletal muscle, we measured the mRNA levels of genes involved in fatty acid metabolism Figure 4 C. Naringin supplementation also lowered elevated plasma lipid concentrations in high-fat-diet—fed rats 60 and decreased plasma lipids and cholesterol in high-cholesterol-diet—fed rats J Agric Food Chem. FGFs and metabolism. Naringenin induced normal plasma levels of adiponectin in HFD-fed mice, independent of genotype Figure 2E. At the baseline visit, upon arrival, weight and vital signs blood pressure and heart rate were measured.

Introduction

Most of these observed benefits were linked to high amounts of vitamin C and folate present in orange juice. Plant flavonoids are capable of lowering increased plasma lipid concentrations 28 New Password. Evaluation of lorcaserin as an anticonvulsant in juvenile Fmr1 knockout mice. Klein S.

Flavonoids—chemistry, metabolism, cardioprotective effects, and dietary sources. Menopause, atherosclerosis, and coronary artery disease. Obesity, metabolic syndrome, naringenin and adiposity diabetes are strongly correlated with inflammatory response. Diabetes ; 52 —61 [ PubMed ] [ Google Scholar ]. However, the effects of OVX on blood triacylglyceride and non-esterified fatty acids are mixed. The metabolic rate peaked at 3.

  • FGF21 acts centrally to induce sympathetic nerve activity, energy expenditure, and weight loss. Lowered adiposity and TG contents in parametrial adipose tissue.

  • Google Scholar J Nutr Sci Vitaminol Tokyo—

  • LinkGoogle Scholar 5. Vascular endothelial growth factor VEGF stimulates the proliferation of VSMCs and increases the expression of proinflammatory and prothrombotic molecules in atherosclerotic plaques

  • Therefore, naringenin does not require FGF21 to mediate is effects. RRA: provided statistical modeling and analysis.

In vivo quantification of subcutaneous and visceral adiposity by micro-computed tomography in a small animal adiposit. Moreover, the concentration of naringenin sulfates was much higher than that of naringenin glucuronides. The main limitation of this study is that a single subject participated; therefore, the data generated prevented a clear generalized statement about the role naringenin played over 8 weeks. Understanding weight gain at menopause. RMR, resting metabolic rate.

Serum total cholesterol and insulin concentrations reduced; however, HDL-C also decreased. Electronic supplementary material The online version of this article doi Week 8 marked the subject's last visit and involved repeating the baseline testing. Differential susceptibility to obesity between male, female and ovariectomized female mice.

Publication types

Kaaja RJ: Metabolic syndrome and the menopause. Search all Naringenin and adiposity articles Search. Borradaile NM, de Dreu LE, Huff MW: Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.

Address correspondence to: Frank L. Candida J. Murray W. Inhibition of Net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation.

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Article Google Scholar Womens Health Lond Engl5: — Accepted : 23 December Conclusion: Dietary naringenin attenuates many of the metabolic disturbances associated with ovariectomy in female mice. Article Google Scholar.

Increased visceral fat and pro-inflammatory activity have been observed naringenin and adiposity postmenopausal women [ 4344 ]. We did not observe differences in spontaneous physical activity and in energy expenditure between groups after controlling for body weight. Reprints and Permissions. Naringenin supplementation attenuated these estrogen-deficiency-associated metabolic disturbances in OVX female mice, suggesting the potential influence of dietary naringenin on metabolic syndrome in postmenopausal women.

We naringenkn observed that mice fed naringenin and adiposity naringenin diet had less hepatic lipid accumulation with corresponding alterations of hepatic gene expression associated with de novo lipogenesis, fatty acid oxidation, and gluconeogenesis. Blood pressure mmHg a. Natural medicines used in the traditional Chinese medical system for therapy of diabetes mellitus. Inflammation: the link between insulin resistance, obesity and diabetes.

Erlund I, Meririnne E, Alfthan G, Aro A: Plasma naringenin and adiposity and urinary excretion of the flavanones naringenin and hesperetin in humans after ingestion of orange juice and grapefruit juice. These changes of body composition increase the risk of developing metabolic syndrome [ 2 ], non-alcoholic fatty liver disease [ 3 ], and heart disease [ 4 ]. Intra-abdominal and subcutaneous adiposity was evaluated by magnetic resonance imaging MRI. Accepted : 23 December Nutrients2: — Yoshida et al. In the present study, we tested the effects of naringenin on metabolic disturbances resulting from estrogen deficiency in ovariectomized mice.

Sarker, no conflicts of interest. J Agric Cruciferous veggies and hypothyroidism Chem ;— However, food intake was not affected by the addition of naringenin data not shown. The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome. Eur J Nutr. Naringin supplementation 0. Amy C.

Naringenin decreases progression of atherosclerosis by improving dyslipidemia in high-fat—fed low-density lipoprotein receptor—null mice. Dietary flavonoids as antioxidants. Naringin and its aglycone naringenin belong to this series of flavonoids and were found to display strong anti-inflammatory and antioxidant activities.

Figure 1. Grapefruit, raw color not specified C. As recently reported in mice fed a HFD or a ketogenic diet, deletion of Fgf21 elevated plasma insulin 36 Burke, Brian G. USDA database for the flavonoid content of selected foods. The effects of grapefruit on weight and insulin resistance: relationship to the metabolic syndrome.

Plasma leptin and leptin mRNA in adipose depots were also decreased in mice fed cruciferous veggies and hypothyroidism naringenin diet. Objective: Adverse metabolic changes associated with loss of ovarian function increase the risk of developing metabolic syndrome and non-alcoholic fatty liver disease NAFLD in postmenopausal women. Intra-abdominal and subcutaneous adiposity was evaluated by magnetic resonance imaging MRI. In the present study, we tested the effects of naringenin on metabolic disturbances resulting from estrogen deficiency in ovariectomized mice.

Following the lipid extraction, triacylglycerol and diacylglycerol were obtained using solid-phase extraction [ 20 ] and solubilized in tert-butanol, methanol, Triton X [ 21 ]. Glucose was measured from tail vein blood using a OneTouch Ultra blood glucose meter immediately prior to insulin injection time 0 and 15, 30, 45, 60, 90, and minutes following the injection. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to chow-fed controls.

  • In a scan time of 16 seconds, views were acquired in one continuous rotation. However, the effects of naringenin on adipose depot mass and metabolic abnormalities associated with estrogen deficiency have not been studied.

  • The chloroform phase was transferred to a weighed test tube and dried under nitrogen gas at room temperature.

  • Fibroblast growth factor 21 reduces the severity of cerulein-induced pancreatitis in mice.

  • The latter effect has been linked to the browning of WAT, increased energy expenditure, and reduced adipose tissue mass with FGF21 treatment 2731 Effect of resveratrol on fat mobilization.

  • Estrogen deficiency leads to metabolic changes and increased risk of metabolic syndrome [ 1 — 330 ]. In addition, as mentioned earlier, we did not design this study to include a pair-fed group since previous studies evaluating metabolic effects of diets with naringenin in male rodents did not observe differences in food intake.

These findings are consistent with human data demonstrating decreased free-living and 24 h energy expenditure, and reduced physical activity during the menopausal transition [ 40 ]. Physiologic parameters such as the electrocardiography, respiration and the temperature of the animals were monitored using a small animal monitoring system ModelSmall Animals Instruments, Inc. RRA: provided statistical modeling and analysis. Received : 22 September Conclusions: These studies highlight the potential therapeutic utility of naringenin and suggest that this flavonoid maintains potent metabolic properties in the absence of obesity or a high-fat diet. Download PDF. Due to the atrophy of the uterus observed in our OVX mice, we could not measure the weight of uterus to determine whether there is an estrogenic or anti-estrogenic effect of naringenin.

Additionally, adiposity significantly reduced perigonadal adipose tissue mass, even after controlling for body weight. Gen Comp Endocrinol— After a 5h-fast, insulin narihgenin administered intraperitoneally at a dose of 0. Graphical representation of the calculated area under curve AUC between time point 0 to min was shown on the top right. Eur J Nutr— Effects of dietary naringenin on caloric intake, body weight, and metabolic measurements.

However, several other molecular signaling pathways naringenin and adiposity by naringin were also revealed recently. Effect of chronic administration of fruit extract Citrus unshiu Marc. All authors read, wrote sections of the manuscript, and approved the final manuscript. Genes Dev.

The totality of evidence suggests that reduced energy expenditure and increased energy efficiency, rather than overeating, results naringenin and adiposity the menopause-associated metabolic disturbances. Borradaile NM, de Dreu LE, Huff MW: Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. J Steroid Biochem Mol Biol65— Additionally, we found increased hepatic expression of genes controlling gluconeogenesis in the mice fed naringenin, a normal physiological reaction in response to fasting.

  • Naringenin prevents dyslipidemia, apolipoprotein- B overproduction, and hyperinsulinemia in LDL receptor—null mice with diet-induced insulin resistance. Lindstrom P.

  • The totality of evidence suggests that reduced energy expenditure and increased energy efficiency, rather than overeating, results in the menopause-associated metabolic disturbances. There were several limitations of the present study.

  • Networking antioxidants in the isolated rat heart are selectively depleted by ischemia-reperfusion. Reza, and S.

  • Both genotypes showed increased weight gain compared with chow-fed mice.

  • At week 22, mice were fasted for 5 h, anesthetized with isoflurane for blood collection via cardiac puncture, and then euthanized by cervical dislocation. Adv Nutr5: —

TABLE 4 Effect of naringin adiposity naringenin on insulin resistance and diabetes in animal and cell adiposiy 1. After a 5h-fast, insulin was administered intraperitoneally at a dose of 0. Body weight during a menstrual cycle should not vary more than 1. A 60 day double-blind, placebo-controlled safety study involving Citrus aurantium bitter orange extract. J Clin Endocrinol Metab.

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Dietary naringenin attenuated hyperglycemia and hyperinsulinemia induced by a high-fat or a fructose-enriched diet [ 1233 ]. Search all BMC articles Search. Kaaja RJ: Metabolic syndrome and the menopause. Borradaile NM, de Dreu LE, Huff MW: Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. At week 22, mice were fasted for 5 h, anesthetized with isoflurane for blood collection via cardiac puncture, and then euthanized by cervical dislocation.

Naringenin and adiposity AS, Elahi D: The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women. Effects of dietary naringenin on adiposity, plasma adipokines, and adipose tissue gene expression. Menopause— Carr MC: The emergence of the metabolic syndrome with menopause. Lipid content in liver and muscle and expression of relevant genes in adipose tissue, liver, and muscle were quantified.

  • There were no clinically significant changes in blood safety markers Table 2.

  • J Nutr Biochem— No differences in mRNA levels of genes related to steatotic liver [ 2829 ] were detected, e.

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Subcutaneous fat was calculated by subtracting intra-abdominal fat from total fat. Borradaile NM, de Dreu LE, Huff MW: Inhibition of net HepG2 cell apolipoprotein Abd secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Adv Nutr5: — These similarities make ovariectomized mice a good model to study physiological changes after menopause. Body weights were significantly reduced in the NAR group from week 12 until the end of the study Figure 1 B.

Therefore, we examined muscle lipid levels and found naringenin reduced the extracted total lipids levels Figure 3 G but had no effect on either triacylglyceride Figure 3 H or diacylglyceride levels in skeletal muscle data not shown. Such data further suggest that the effect of naringenin on adiposity is not simply attributable to lower caloric intake. J-YK: contributed to the design of the study, performed the experiments, conducted data analysis and obtained external support for the work. We report here that OVX mice exhibited metabolic disturbances expected with estrogen deficiency including elevated fasting glucose and obesity [ 32631 ]. About this article. Hyperphagia has been reported in some models of menopause [ 37 ] but not all [ 1736 — 38 ]. Naringenin supplementation attenuated these estrogen-deficiency-associated metabolic disturbances in OVX female mice, suggesting the potential influence of dietary naringenin on metabolic syndrome in postmenopausal women.

Lack of induction of these two genes in naringenin and adiposity CON mice may be related to their naringeenin levels of fasting glucose. Electronic supplementary material. Article Google Scholar. Borradaile NM, de Dreu LE, Huff MW: Inhibition of net HepG2 cell apolipoprotein B secretion by the citrus flavonoid naringenin involves activation of phosphatidylinositol 3-kinase, independent of insulin receptor substrate-1 phosphorylation. Article Google Scholar

The ability of naringenin to modulate metabolic pathways linked to the metabolic syndrome suggests citrus flavonoids represent valuable tools in the search for regulators of insulin signaling, lipid homeostasis, and energy balance. Statistical analysis was performed using SPSS version Mediators Inflamm. Blood was collected for a chemistry panel glucose, insulin, creatinine, potassium, uric acid, albumin, calcium, magnesium, creatine phosphokinase, alanine aminotransferase, alkaline phosphatase, iron, total cholesterol high-density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C], and triglycerides and a complete blood count. Electronic supplementary material The online version of this article doi

Dawn E. Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. An FGFadiponectin-ceramide axis controls energy expenditure and insulin action in mice. Release 3.

Associated Data

Terao J: Dietary flavonoids as antioxidants. After a 5h-fast, insulin was administered intraperitoneally at a dose of 0. We demonstrated that naringenin decreased plasma cholesterol but did not change the levels of plasma triacylglyceride and non-esterified fatty acids in OVX mice.

Naringin and naringenin supplementation has proven to be efficacious for the treatment of metabolic syndrome and obesity in animal models 60 Citrus fruits such as oranges, mandarins, grapefruit, and acid citrus fruits, namely lemons, bergamots, and limes, are notably rich in flavonoid content and possess various bioactivities. A beneficial effect of naringin was observed in LDLR-null mice fed a high-fat diet Bailey DG.

Google Scholar Crossref. Ameer B, Weintraub RA. Compared to baseline, the body weight decreased by 2. Because naringenin is a potent activator of hepatic FA oxidation, we hypothesized that induction of FGF21 might be an integral part of naringenin's mechanism of action. Lipids Health Dis ; 10 Naringin supplementation decreased TNF release and improved liver injury

Materials and Methods

There were also cruciferous veggies and hypothyroidism differences in ambulatory activity Figure 1 C and energy expenditure after controlling for body weight differences between groups Figure 1 D. Estrogen deficiency leads to metabolic changes and increased risk of metabolic syndrome [ 1 — 330 ]. Accepted : 23 December

Previous studies narinenin adipose tissues inflammation occurred early in OVX mice e. Fruit juice inhibition of uptake transport: a naringenin and adiposity type of food—drug interaction. Shepherd PR, Kahn BB : Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus. Electronic supplementary material The online version of this article doi Naringin supplementation also lowered elevated plasma lipid concentrations in high-fat-diet—fed rats 60 and decreased plasma lipids and cholesterol in high-cholesterol-diet—fed rats Nat Commun ; Both genotypes showed increased weight gain compared with chow-fed mice.

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Otsu segmentation [ 1 ] was used to segment the mouse body from background. Figure 4. The abdominal cavity was manually outlined in the images and a naringfnin threshold of grey level intensity was chosen to segment fat from surrounding tissue. There were also no differences in ambulatory activity Figure 1 C and energy expenditure after controlling for body weight differences between groups Figure 1 D. Accepted : 23 December Blood was collected into EDTA-coated blood collection tubes and plasma was obtained after centrifugation.

After a 5h-fast, insulin was administered intraperitoneally at a dose of 0. To our knowledge, this is nringenin first paper to examine the effects of naringenin on energy metabolism and adiposity in OVX female mice, a preclinical model of menopause. These changes of body composition increase the risk of developing metabolic syndrome [ 2 ], non-alcoholic fatty liver disease [ 3 ], and heart disease [ 4 ]. Srebf1, Fasn, and Scd1 encode proteins involved in de novo lipogenesis. Menopause—

High body fat also increases the risk of several diseases such as diabetes, hyperlipidemia, and hypertension, which leads to arteriosclerotic disease and metabolic syndrome We conducted an adiposity case study. J Food Drug Anal. Thus, there is a growing interest in dietary bioactive compounds that protect against or mitigate the severity of chronic diseases without the undesirable side effects. References 1. Effect of Naringin on Cardiac Toxicity, Hypertrophy, and Remodeling The cardioprotective effects of flavonoids are well documented Table 3 2873 ,

During menopause, many women experience weight gain and accumulation of body fat in the waist region [ 1 ]. The authors thank Josephine Fouts for assistance with mouse experimentation, and Dr. Such data further suggest that the effect of naringenin on adiposity is not simply attributable to lower caloric intake.

  • Meydani M, Hasan ST. At the time of this study, A.

  • Nutrition—

  • Naringin and naringenin both are strong scavengers of free radicals and prevent lipid peroxidation

  • Panel C shows representative coronal MRI views from each group. The abdominal cavity was manually outlined in the images and a global threshold of grey level intensity was chosen to segment fat from surrounding tissue.

  • Eur J Nutr— Ke, JY.

  • Hainer V : Beta3-adrenoreceptor agonist mirabegron—a potential antiobesity drug?

Naringenin may be useful for ameliorating the inflammatory changes in obese adipose tissue. Table naringenin and adiposity. Link narinvenin, Google Scholar 5. Suppression of hepatic oxidative events and regulation of eNOS expression in the liver by naringenin in fructose-administered rats. Central effects of estradiol in the regulation of food intake, body weight, and adiposity.

Respiratory quotient and the stoichiometric approach and hypothyroidism investigating metabolic energy substrate use in aquatic ectotherms. Burnier M, Brunner HR. Narinegnin in a separate window. Determination of naringin and naringenin in human urine by high-performance liquid chromatography utilizing solid-phase extraction. We observed development of hyperglycemia in OVX mice from week 5 to week 18, consistent with Roger et al. This implies that correction of metabolic abnormalities by naringenin in this model is independent of any difference in adipose tissue stores.

Open in new tab Download slide. Increased visceral fat and pro-inflammatory activity have been observed in postmenopausal women [ 4344 ]. J Steroid Biochem Mol Biol. Bailey DG.

Additionally, naringenin significantly reduced perigonadal adipose tissue mass, even after controlling for body weight. The naringenin and adiposity effects of flavonoids are well documented Table 3 2873 Normalized the concentrations of plasma TBARS, lipid hydroperoxides and vitamin E and reduced glutathione in diabetic rats. High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats.

Skip to main content. You can also search for this author in PubMed Google Scholar. Naringenin and adiposity visceral fat and pro-inflammatory adipostiy have been observed in postmenopausal women [ 4344 ]. Although exogenous estrogen has been shown to be protective against many menopause-related metabolic abnormalities, long-term usage of hormone replacement therapy may increase the risk of breast cancer in addition to negative implications for cardiovascular diseases in postmenopausal women [ 5 ]. Figure 3.

Therefore, we naringenin and muscle lipid levels and found naringenin reduced the extracted total lipids levels Figure 3 G but had no effect on nnaringenin triacylglyceride Figure 3 H or diacylglyceride levels in skeletal muscle data not shown. J Lipid Res— Due to the atrophy of the uterus observed in our OVX mice, we could not measure the weight of uterus to determine whether there is an estrogenic or anti-estrogenic effect of naringenin. Energy expenditure was measured by indirect calorimetry and activity was monitored by infrared beam breaks. In the present study, we found that mice developed higher fasting glucose, adiposity, and hepatic steatosis after loss of ovarian function, similar to what has been observed in postmenopausal women [ 331 ]. Measurements were taken for a h period, including a h light cycle and a h dark cycle.

The abdominal cavity was manually outlined in the images and a global threshold of grey level adposity was chosen to segment fat from surrounding tissue. Body weight and food intake were measured daily. Additional information Competing interests The authors declare that they have no competing interests. However, no difference was observed in areas under the curve AUC between groups.

  • Am J Clin Nutr.

  • Article Google Scholar

  • Immature Citrus sunki peel extract exhibits antiobesity effects by beta-oxidation and lipolysis in high-fat diet-induced obese mice.

The other authors have nothing to declare. It is possible that OVX adiposiry no effect on triacylglyceride and non-esterified fatty acids in the current study. Clinical Findings for Citrus Fruit Juices and Their Active Component Naringin Most beneficial effects found for citrus flavonoids were mainly based on animal and in vitro cell culture studies, which may be relevant in explaining mechanisms of the bioactive components present in citrus fruits. Eur J Clin Nutr ;—

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Naringenin improves metabolic disturbances in vitro and in vivo. It is possible that OVX had no effect on triacylglyceride and non-esterified fatty acids in naringenin and adiposity current study. J Agric Food Chem— Graphical representation of the calculated area under curve AUC between time point 0 to min was shown on the top right. In the present study, we tested the effects of naringenin on metabolic disturbances resulting from estrogen deficiency in ovariectomized mice. Reprints and Permissions. Womens Health Lond Engl5: —

Effect of Naringin on Cardiac Toxicity, Naringenin and, and Remodeling The cardioprotective effects of flavonoids are well documented Table 3 2873 The accumulation of cholesteryl ester CE within the arterial intima is an initiating factor in atherogenesis Mol Endocrinol. Wisse BE. Maurya and Dr. Naringenin prevents dyslipidemia, apolipoprotein- B overproduction, and hyperinsulinemia in LDL receptor—null mice with diet-induced insulin resistance. Pretreatment with various doses of naringin inhibited the doxorubicin-induced decline in antioxidant status and reduced the concentrations of 8-OHdG and the activity of poly ADP-ribose polymerase PARP in heart and liver of mice

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Figure 4. Curr Opin Pharmacol— Hong et al. Download references.

Additional information Competing interests The authors declare that they have no competing interests. However, the effects of OVX on blood triacylglyceride and non-esterified fatty acids are mixed. Nutrition— Caloric intake decreased significantly when mice were switched to a naringenin-containing diet at week 12 Figure 1 A without complete recovery to baseline in the following weeks. Blood biochemical measures of metabolic response included glucose, insulin, adipokines, and lipids. Gen Comp Endocrinol—

  • Moreover, vitamin E has no effect on certain ROS, such as hypochlorite-induced oxidation Characterization of orange juice Citrus sinensis by flavanone glycosides.

  • Naringenin is a flavonoid that is abundant in citrus fruits and tomatoes [ 89 ].

  • Uddin, H. Andrew C.

Adipose tissue is highlighted in red. LDY: contributed to data interpretation. Naringenin and adiposity neurons under the magnifying glass. Flavonoids are strong anti-inflammatory compounds Adipose tissue inflammation and reduced insulin sensitivity in ovariectomized mice occurs in the absence of increased adiposity.

Endocrinologyanf Menopause Int21— We observed development of hyperglycemia in OVX mice from week 5 to week 18, consistent with Roger et al. Abstract Objective: Adverse metabolic changes associated with loss of ovarian function increase the risk of developing metabolic syndrome and non-alcoholic fatty liver disease NAFLD in postmenopausal women. Plasma leptin and leptin mRNA in adipose depots were also decreased in mice fed a naringenin diet.

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Ryan AS, Elahi D: The effects of acute hyperglycemia and hyperinsulinemia on plasma leptin levels: its relationships with body fat, visceral adiposity, and age in women. After a 5h-fast, insulin was administered intraperitoneally at a dose of 0. Body weights were significantly reduced in the NAR group from week 12 until the end of the study Figure 1 B.

Database Oxford. Naringenin and adiposity the cardioprotective effects of flavonols: discovery of relaxant flavonols without antioxidant activity. Hyperglycemia and insulin resistance are common features narimgenin metabolic syndrome. Therefore, the improvement in insulin sensitivity may be attributed to the effects of naringenin on body weight, metabolic rate, and upregulation of target genes, but their individual contribution remains to be determined. However, it is unclear whether this effect is a direct effect of naringenin on WAT or secondary to effects at other sites. Hypolipemic and hypoglycaemic activity of bergamot polyphenols: from animal models to human studies.

Naringenin readily accumulates in plasma after hypothyroidism of orange juice, grapefruit juice [ 52 ], and tomato paste or sauce [ 53 ], suggesting that anr is bioavailable in individuals who consume naringenin food sources regularly. However, in these models, a significant effect of naringenin supplementation is the prevention of weight gain, which in itself can confer metabolic protection. Additionally, we did not have sham-operated mice as a control to evaluate the degrees of metabolic disturbances in our OVX mice and thus the extent of naringenin effects. CAS Google Scholar. Effects of dietary naringenin on adiposity, plasma adipokines, and adipose tissue gene expression. Furthermore, naringenin treatment reduces plasma lipids and enhances insulin sensitivity compared to chow-fed controls.

Naringenin inhibited apoB secretion by activating signaling cascades in HepG2 cells Dietary polyphenols and obesity. Grapefruit, raw color not specified C. Kharitonenkov A.

Dietary naringenin attenuated hyperglycemia and hyperinsulinemia induced by a high-fat or a fructose-enriched naringenin and adiposity [ 1233 ]. J Nutr Biochem— Arterioscler Thromb Vasc Biol— We did not observe differences in spontaneous physical activity and in energy expenditure between groups after controlling for body weight.

  • Energy expenditure was measured by indirect calorimetry and activity was monitored by infrared beam breaks.

  • Lipid content in liver and muscle and expression of relevant genes in adipose tissue, liver, and muscle were quantified. Endocrinology—

  • Naringenin is a flavonoid that is abundant in citrus fruits and tomatoes [ 89 ].

  • Grundy SM. Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.

Received : 22 September Graphical representation of the calculated area under curve AUC between time point afiposity to min was shown on the top right. The abdominal cavity was manually outlined in the images and a global threshold of grey level intensity was chosen to segment fat from surrounding tissue. MAB: designed the study, obtained external support for the work, and oversaw data analysis and interpretation. The totality of evidence suggests that reduced energy expenditure and increased energy efficiency, rather than overeating, results in the menopause-associated metabolic disturbances.

Goldwasser et al. We also observed that mice fed a naringenin diet had less hepatic lipid accumulation with corresponding alterations of hepatic gene expression associated adippsity de novo lipogenesis, fatty acid oxidation, and adiposity. Srebf1, Fasn, and Scd1 encode proteins involved in de novo lipogenesis. Effects of dietary naringenin on adiposity, plasma adipokines, and adipose tissue gene expression. Am J Clin Nutrs— Appl Physiol Nutr Metab— Naringenin readily accumulates in plasma after ingestion of orange juice, grapefruit juice [ 52 ], and tomato paste or sauce [ 53 ], suggesting that it is bioavailable in individuals who consume naringenin food sources regularly.

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