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Obje ili obese: Eight-Year Weight Losses with an Intensive Lifestyle Intervention: The Look AHEAD Study

Show More. Kuna has received research support from Philips Respironics.

Matthew Cox
Tuesday, February 16, 2021
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  • The publisher's final edited version of this article is available at Int J Obes Lond.

  • Compared to non-apneic individuals, OSA patients were shown to have significantly increased percentage of stage 1 sleep, as well as significantly decreased percentage of stage 2, REM sleep, and SWS.

  • This contrasts with school aged children, where live attenuated influenza vaccination was shown to reduce risk for laboratory confirmed influenza similarly for healthy weight and obese Body weight data for participants who died during the 8-year trial were included in the analyses until censored at the time of death.

  • Considering that obese manipulation studies have demonstrated an important role of SWS in influencing glucose metabolism, 741 it is surprising that the ILI in these obese patients with T2D did not induce significant increases in SWS, and that this sleep stage was not associated with decreased body weight or OSA severity. Address correspondence to: Ari Shechter, Ph.

Što je dinamički disk?

Indeed, vaccinated elderly adults are also less jli from influenza infection despite having an adequate serological response, which has been attributed to poor T cell responses Look AHEAD is the longest randomized controlled evaluation to date of an intensive lifestyle intervention for weight management. Data presented in tables were analyzed using R

Participants were strongly encouraged but not required to attend the various group offerings. Year-8 obees was In addition, all analyses were conducted with and without censoring weights of participants in both groups who underwent bariatric surgery. Data presented in Figure 1 were analyzed using Graphpad Prism 6. Figure 4 c.

  • The risk ratio estimate obese similar when adjusting for vaccine year, age, sex, and smoking status using log-binomial regression 2. Protection against influenza infection increases up to an HAI titer ofbeyond which further protective capacity is minimal

  • Report message as abuse. Effect of surgical weight loss on sleep architecture in adolescents with severe obesity.

  • Clin Infect Dis. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes.

  • Xavier Pi-SunyerM.

Obje ili of sleep fragmentation on glucose metabolism in normal subjects. For these repeated-measure analyses, changes in variables over time were considered in the model. Clinical Trial Registration: ClinicalTrials. We hypothesized that the weight loss intervention and its subsequent reductions in OSA severity would be associated with improvements in nocturnal sleep architecture. In a study exploring the association between dietary patterns and sleep disordered breathing, Vasquez et al. Polysomnography before and after weight loss in obese patients with severe sleep apnea. Intrascorer reliability across the 4 years was assessed by having the masked scorer rescore a subset of 92 randomly selected PSGs.

We iili that the obese loss intervention and its subsequent reductions in OSA severity would be associated with improvements in nocturnal sleep architecture. This included 47 from baseline, 20 from year 1, 8 from year 2, and 17 from year 4. Although the intervention was effective in reducing the severity of OSA over a 4-year period, it did not lead to changes in the various PSG measures, suggesting that the ILI did not induce changes in sleep architecture, duration, or continuity across the 4-year follow-up. Sleep stages were expressed as percentage of TST.

Što je osnovni disk?

Problem obeese bio pronaci dovoljno tanak kabel koji moze uci u utore. Role of Unintended pregnancy health consequences of obesity and Body Weight in Influencing Sleep Architecture: Repeated-Measure Mixed-Model Analyses Repeated-measure mixed-model analyses were used to determine how various factors, including intervention group, time year of assessmentand changes in AHI and body weight affect sleep duration, continuity, and architecture throughout the 4-year follow-up period for all participants Table 3. Analyses were adjusted for sex, age, race, and treatment site. Changes from baseline for these parameters were adjusted for sex, age, race, and treatment site. A total of 5, persons aged 45 to 76 years were randomly assigned to either ILI with reduced calorie consumption and increased physical activity or diabetes support and education intervention DSE.

  • Supplementary Material 1 Click here to view. Appendix Authors: Thomas A.

  • However, when results were further analyzed as a longitudinal pooled observation study in which participants from the two groups were combined, we found that changes in sleep architecture i. Conclusions: Compared to control, the ILI did not induce significant changes in sleep across the 4-year follow-up.

  • External link. Relationship between haemagglutination-inhibiting antibody titres and clinical protection against influenza: development and application of a Bayesian random-effects model.

  • Epidemiol Infect. Physical activity and weight loss: does prescribing higher physical activity goals improve outcome?

  • Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: Results from an ancillary Look AHEAD study. The authors thank Ms.

  • Sleep apnea and sleep disruption in obese patients.

We thank Savanna Ledford and Qing Shi for technical obje ili obese. Their weight loss also could have been unintentional 39 and reflect the effects of aging 40 or illness 39 including diabetes 36as discussed with weight loss in older ILI participants. In year 1, 5 ILI and 10 DSE participants had surgery, which increased by year 8 to a total of 76 and 84, respectively the latter values representing 3. Logistic regression analyses clearly revealed the importance of successful first-year weight loss for achieving a clinically meaningful loss at year 8.

Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. Recordings at baseline, year 1 and year 2 were done using the Compumedics PS2 monitor Compumedics Sleep, Abbotsville, Australiawhereas recordings at year 4 were done using the Compumedics Safiro monitor. Samuel T. WingPh. A total of 5, persons aged 45 to 76 years were randomly assigned to either ILI with reduced calorie consumption and increased physical activity or diabetes support and education intervention DSE.

Associated Data

One dose of — trivalent inactivated influenza vaccine 0. Jeffery, PhD; Karen C. Effect of intensive lifestyle intervention on sexual dysfunction in women with type 2 diabetes: Results from an ancillary Look AHEAD study.

  • Weights of participants who died were censored at the time of death.

  • Some limitations were present in the current study. Enjoying our content?

  • However, Murphy et al.

  • In the — vaccine year, vaccination of participants started on September 15, and were completed on October 28,

  • Structured meal plans 22 and meal replacements 18 were provided free of charge for the first 4 months, with patients encouraged to replace two meals and one snack daily with liquid shakes and meal bars. Try out PMC Labs and tell us what you think.

  • Notably, HAI antibody titers, widely viewed as correlates of protection against influenza, were unreliable as predictive of disease protection in obese adults.

The four categories of weight change that these participants achieved at year 8 are presented obese the same manner as in Figure 4 A. New Engl J Med. Older DSE participants lost more weight than their younger counterparts, with the greatest difference 1. World Health Organization. Pre and post vaccination titers were not statistically different among healthy weight white with open circlesoverweight checkered with black circles or obese grey with grey circles participants. Data presented in tables were analyzed using R Association of an intensive lifestyle intervention with remission of type 2 diabetes.

Additionally, MN titers in obese adults were also inadequate predictors of protection and these studies directly correlate with studies conducted in obese mice Therefore, with a growing obesity epidemic, complications from influenza infection would be expected to increase. One obvious hypothesis for the increase in influenza and ILI in obese adult participants is a failure to seroconvert or reach seroprotective levels of antibody. Diet and exercise interventions reduce intrahepatic fat content and improve insulin sensitivity in obese older adults. Participants were recruited as a part of a prospective observational study carried out at the University of North Carolina at Chapel Hill Family Medicine Center, an academic outpatient primary care facility in Chapel Hill, North Carolina. However, the risk of developing influenza or ILI in a vaccinated obese adult population has not been addressed.

In terms of factors influencing obesity, sleep fragmentation intervention that reduced stage 2 and REM sleep but not TST resulted in decreased next-day levels of glucagon-like peptide-1 a hormonal satiety signal and feelings of fullness. Statistical Analyses Adjusted change from baseline was calculated for all sleep architecture parameters at year 1, year 2, and year 4. Finally, it should be pointed out that results of the current study may not necessarily be generalized to patients without T2D, or patients with less severe OSA. Taken together, this may imply that methods to reduce AHI and improve sleep architecture should be encouraged for obese OSA patients to improve dietary patterns and metabolic health. Na kraju sam raskopao 80 zilni IDE kabel i nekako nagurao.

The risk ratio estimate was similar when adjusting for vaccine year, age, sex, and smoking status using log-binomial regression 2. Pediatr Infect Dis J. Mortality associated with influenza and respiratory syncytial virus in the United States. Weight losses of African Americans were among the largest reported in the literature. Figure 1.

Disk sam ubrzo zamijenio, umjesto 40GB uzeo GB. Sustained improvement in mild obstructive sleep apnea after a diet- and physical activity-based lifestyle intervention: postinterventional follow-up. Eur Respir J. Polysomnography before and after weight loss in obese patients with severe sleep apnea. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. Na kraju sam skuzio kako sam, nakon ciscenja lece, slucajno ostetio maleni tanki kabel koji napaja IC detektor zraka koju disk prekine i na taj nacin signalizira konzoli da pokrene loading mehanizam. Try out PMC Labs and tell us what you think.

Baseline sleep parameters did not differ between groups, and are summarized in Table 1. Br J Nutr. Sleep quality and duration before and after bariatric surgery. Look AHEAD is a center randomized clinical trial investigating the long-term effects of weight loss on cardiovascular morbidity and mortality in overweight and obese T2D patients. Associations between short sleep duration and central obesity in women.

Laboratory confirmed influenza infection was determined from the medical records which reported a positive influenza obje ili obese using the FDA cleared Cepheid Xpert Flu assay Cepheid, Sunnyvale, CA. Author information Copyright and License information Disclaimer. Therefore, alternative approaches may be needed to protect obese adults from both seasonal and pandemic influenza virus infection. Kumanyika SK.

The publisher's final edited version of this ibese is available at Int J Obes Lond. Author manuscript; available in PMC Jul 1. Neidich1 William D. The same statistical differences were observed between the ILI and DSE groups when including or censoring weight losses of participants who had bariatric surgery. In the — vaccine year, vaccination of participants started on September 15, and were completed on October 28, Learn More.

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This article has been cited by other articles in PMC. JakicicPh. Registration is free. Home » Topics » Prevention.

Sam S. There were no statistical differences in seroprotection or seroconversion rates between healthy weight and obese adults. Author manuscript; available in PMC Jul 1. However, here we found that an HAI antibody titer of 40 or higher was not a serological correlate for vaccine-induced protection and did not prevent laboratory confirmed influenza and ILI in obese adults. Successful weight loss maintenance.

Laboratory confirmed Influenza and ILI compared to non-illness reporting matched controls All 74 participants with either laboratory confirmed or ILI were matched with non-illness reporting participants and their demographics are shown in Supplemental Table 1. Karlsson 3 Department of Infectious Diseases, St. Each year, vaccines are formulated based on evaluations of previously circulating influenza strains. To determine if obesity altered the risk of developing influenza or ILI in a vaccinated adult population, we report the incidence of influenza infection and influenza-like illness ILI in vaccinated obese and healthy weight adults as well as the extent to which participants with influenza infection and ILI produced influenza specific antibodies. The Jonckheere—Terpstra test was employed to assess associations between baseline covariates and the ordinal weight category. Trial Registration clinicaltrials.

Polysomnography before and after weight loss in obese patients with severe sleep apnea. KunaM. Impact of insufficient sleep on total daily energy expenditure, food intake, and weight gain. Body weight measured in kg was assessed at the annual clinic visit by blind assessors, and was done within 1 week of PSG recordings.

A self-regulation program for maintenance of obje ili obese loss. Corresponding Author: Melinda A. The findings reported here demonstrate that, compared to vaccinated healthy weight adults, vaccinated obese adults were 2X more likely to develop influenza infection and ILI. J Conult Clin Psychol. External link. Copyright notice.

These sleep fragmentation studies may be particularly relevant for patients with OSA since the intermittent hypoxia associated with the disorder results in frequent nocturnal arousals and sleep architecture disruption. Taken together, this may imply that methods to reduce AHI and improve sleep architecture should be encouraged for obese OSA patients to improve dietary patterns and metabolic health. Sleep stages were expressed as percentage of TST. Distinct associations between energy balance and the sleep characteristics slow wave sleep and rapid eye movement sleep. Selective slow wave sleep but not rapid eye movement sleep suppression impairs morning glucose tolerance in healthy men. Specifically, selectively suppressing slow wave sleep SWS without affecting total sleep time TST results in reduced glucose tolerance and insulin sensitivity. Current findings further expose the important links that exist between obesity, T2D, sleep disordered breathing, and sleep, and indicate that reducing OSA severity can be associated with improvements in nocturnal sleep architecture.

World Health Organization. Vaccines and Sample Collection One dose of — trivalent inactivated influenza vaccine 0. Exclusion criteria were immunosuppressive diseases including HIV, use of immunomodulatory or immunosuppressive drugs, acute febrile illness, history of hypersensitivity to any influenza vaccine components, history of Guillain-Barre syndrome, use of theophylline preparations, or use of warfarin.

Persistence of obstructive sleep apnea after surgical weight obese. Ari ShechterPh. Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Int J Obes Lond ; 29 — Specifically, selectively suppressing slow wave sleep SWS without affecting total sleep time TST results in reduced glucose tolerance and insulin sensitivity. Diabetes Care. Keywords: sleep architecture, obstructive sleep apnea, obesity, type 2 diabetes.

  • P values are adjusted for clinical site and the log of the baseline value for years 1, 4, and 8.

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  • Geneva, Switzerland: Author;

  • Throughout the 4-year follow-up period, none of the participants received surgical or dental treatment for OSA. Na kraju sam raskopao 80 zilni IDE kabel i nekako nagurao.

  • Critical revision of the manuscript for important intellectual content: All authors.

These behaviors have been identified in prior studies of successful weight loss maintainers. Sci Rep. The Jonckheere—Terpstra ilo was employed to assess associations between baseline covariates and the ordinal weight category. Indeed, vaccinated elderly adults are also less protected from influenza infection despite having an adequate serological response, which has been attributed to poor T cell responses Laboratory confirmed Influenza and ILI compared to non-illness reporting matched controls All 74 participants with either laboratory confirmed or ILI were matched with non-illness reporting participants and their demographics are shown in Supplemental Table 1. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes.

These include prevention and resolution of type 2 diabetes, obje ili obese objee, 12 reduction in blood pressure and lipids, 13 — 14 amelioration of non-alcoholic fatty liver disease, 15 and improvements in urinary incontinence and sexual dysfunction. Consistent with these hypotheses, we predicted that ILI participants, compared with DSE, would report greater practice of numerous weight control behaviors e. Wadden, PhD; John P. Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes. Copyright notice. Figure 4 a.

Bariatric surgery: a systematic review and meta-analysis. He has received grants from Coca Cola Company and Orexigen. Clinical Trial Registration: ClinicalTrials.

Subjects and methods: During the and influenza seasons, we recruited subjects to a prospective observational study of trivalent inactivated influenza vaccine IIV3 in adults. Mislio sam da si ti pisao kako ti je fat riknuo i da si kupio novi slim Published online Nov Since then, a series of more structured, supervised lifestyle intervention studies have been conducted. Weight loss in mildly to moderately obese patients with obstructive sleep apnea.

  • The two sets of analyses yielded the same statistical conclusions concerning differences between groups.

  • Association between sleep architecture and measures of body composition. FosterPh.

  • Hudgens5 Sam S.

  • Baseline sleep parameters did not differ between groups, and are summarized in Table 1.

The percentages shown kbje parentheses are based on the obje ili obese size for the subgroup. Year-8 retention was The publisher's final edited version of this article is available at Int J Obes Lond. There were study subjects who participated in both years of the study, fifteen of which reported ILI in one or both years of the study. Author information Copyright and License information Disclaimer. Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes.

He has received grants from Coca Cola Company and Orexigen. Strohl, M. Thomas A. Our results are somewhat boje line with an obje ili obese study by Smith et al. Subjects and methods: During the and influenza seasons, we recruited subjects to a prospective observational study of trivalent inactivated influenza vaccine IIV3 in adults. Participants who were receiving continuous positive airway pressure CPAP treatment for OSA during the follow-up period were asked not to use the treatment for 3 nights prior to experimental PSG recording. Problem je bio pronaci dovoljno tanak kabel koji moze uci u utore.

Meta-analysis obje ili obese short sleep duration and obesity in children and adults. These time effects oebse that for both groups overall, expression of stage 2 sleep was above baseline and expression of SWS was below baseline values across the year 1, year 2, and year 4 follow-ups. Current results indicate that the improvements in stage 1, stage 2, and REM sleep, are more likely to be influenced by the reduction in OSA severity than by the loss of body weight per se.

  • Assessments of relative risk for laboratory confirmed influenza and influenza-like illness were determined based on BMI. Horton, MD; Van S.

  • Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial. Am J Clin Nutr.

  • The Jonckheere—Terpstra test was employed to assess associations between baseline covariates and the ordinal weight category.

  • The other authors have indicated no financial conflicts of interest. Substances Influenza Vaccines.

  • Diabetes Support and Education Participants in the DSE group were provided with 3 group sessions each year, which focused on diet, physical activity, and social support.

Decreased slow wave sleep increases risk of developing hypertension in elderly men. A growing body of both epidemiological and laboratory-based studies supports a role of short sleep duration in the development of obesity. Weight loss is frequently recommended as a treatment for OSA symptoms in obese individuals, and reductions in OSA severity and concomitant improvements in nocturnal sleep quality have been observed in response to surgical 16 or diet-induced 17 weight reduction. Reply to author. Recordings at baseline, year 1 and year 2 were done using the Compumedics PS2 monitor Compumedics Sleep, Abbotsville, Australiawhereas recordings at year 4 were done using the Compumedics Safiro monitor. Our results are somewhat in line with an earlier study by Smith et al.

ALSO READ: Genetics Linkedin To Obesity Definition

Enjoying our content? J Bone Miner Res. The other authors have indicated no financial conflicts of interest. Kod mene je bio slican problem, bluray drive je prihvacao bluray disk nakon jaceg guranja, ali ga onda nije htio izbaciti van. Int J Obes Lond ; 36 — This included 47 from baseline, 20 from year 1, 8 from year 2, and 17 from year 4. Individuals in the ILI group participated in a group behavioral weight loss program specifically developed for obese T2D patients.

Study Impact: Ilo the weight loss intervention was effective in reducing the severity of OSA over a 4-year period, it did not lead to changes in the various polysomnographic sleep measures, indicating that the ILI did not obje ili obese changes in sleep architecture, duration, or continuity. Results: Among obese, 9. The current study aimed to determine whether the benefits of a structured weight loss intervention program on OSA severity also improved nocturnal sleep duration and architecture in these overweight and obese T2D patients who were found to have OSA at baseline. Anthropometry Body weight measured in kg was assessed at the annual clinic visit by blind assessors, and was done within 1 week of PSG recordings. He has received grants from Coca Cola Company and Orexigen. Pa nije to jedan od prvih xboxova sunceti

In addition to lifestyle interventions encouraging obje ili obese caloric intake and increased physical activity, bariatric surgery is an effective method for inducing weight loss within obese patients, with sustained effects seen in a long-term follow-up. Specifically, REM sleep expression was found to be inversely related to central obesity, and SWS expression was also found to be inversely related to BMI and incident hypertension. Wing RR. In a study exploring the association between dietary patterns and sleep disordered breathing, Vasquez et al.

Authors: Thomas A. Epidemiol Infect. The percentages shown in parentheses are based on the sample size for the subgroup. All statistical analyses were performed using SAS version 9.

Enjoying our content? Sleep apnea obese sleep disruption in obese patients. Login Register. Obes Surg. Look AHEAD Action for Health in Diabetes : design and methods for a clinical trial of weight loss for the prevention of cardiovascular disease in type 2 diabetes. Overnight nasal CPAP improves hypersomnolence in sleep apnea.

ALSO READ: Obesity Dalam Kalangan Kanak Kanak Pintar

Int Ohje Unintended pregnancy health consequences of obesity Lond ; 36 — Factors associated with death or hospitalization due to pandemic influenza A H1N1 infection in California. Under this possibility, the influenza vaccine may equally protect healthy weight and obese adults, however an increased rate of infection exposure in obese adults could lead to an increased rate of infection in vaccinated obese adults compared with healthy weight adults. Therefore we could be over-reporting, as some of the ILI subjects may be positive for a respiratory virus other than influenza, or under-reporting, as the more stringent CDC criteria may miss some milder ILI symptoms that are influenza positive. Therefore, alternative approaches may be needed to protect obese adults from both seasonal and pandemic influenza virus infection. Supplementary Material 1 Click here to view. Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes.

Decreased slow wave sleep increases risk of developing hypertension in elderly men. Filip Lolic. Sleep quality and duration before and after bariatric surgery. Assessments of relative risk for laboratory confirmed influenza and ILI were determined based on body mass index. This article has been cited by other articles in PMC. Effect of surgical weight loss on sleep architecture in adolescents with severe obesity.

Statistical Analyses The present analyses focused on the first 8 years of intervention, which all participants had obese opportunity to complete before the trial was halted in September Association between obesity and vulnerability and serologic response to influenza vaccination in older adults. The geography and mortality of the influenza pandemic. Weight data reported in the primary endpoint paper included participants at different stages of intervention, ranging from 8.

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Effect of a very low energy diet obje ili obese moderate and severe obstructive sleep apnoea in obese men: a randomised controlled trial. Year was treated as a continuous variable in the mixed-model analyses. Meta-analysis of short sleep duration and obesity in children and adults. We hypothesized that the weight loss intervention and its subsequent reductions in OSA severity would be associated with improvements in nocturnal sleep architecture. Associations between short sleep duration and central obesity in women.

Differences between the DSE and ILI obrse in changes in weight over the 8 years were analyzed using a mixed effects analysis of covariance, obje ili obese included baseline weight, clinical center, and treatment arm. As T cells are necessary for protection and recovery from influenza, impaired T cell function, despite a robust serological response, may render vaccinated obese adults more susceptible to influenza infection. Scott D. References 1. Changes in body mass index and weight before and after the development of type 2 diabetes. Medical records of all study participants, whether they reported ILI or not, were reviewed at the end of each season for medically reported influenza-like illness or laboratory confirmed influenza.

Figure 4 b. Several studies have suggested that overweight and obesity impairs vaccine response to several pathogens. Participants returned 26—35 days later for a post-vaccination blood draw. Diabetes Prevention Program Research Group. Participants who did not complete outcome assessments in years 1 through 8 had either died, withdrawn from the study, or missed the assessment. Serological responses to influenza vaccination are typically assessed as seroprotection, defined as an HAI titer of 40 or greater post vaccination, or seroconversion, defined as a 4 fold or greater increase in HAI from prevaccination titer to post vaccination titer.

The percentage of SWS and REM sleep was negatively correlated with next-day intakes of fat and carbohydrates when participants were given an ad libitum eating opportunity. NewmanM. Diab Vasc Dis Res.

Please review our privacy policy. Figure 4 a. Factors associated with death or hospitalization due to pandemic influenza A H1N1 infection in California. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Supplementary Material Click here to view.

  • Height and obje ili obese were measured and a baseline serum sample drawn. The Diabetes Prevention Program Outcomes Study 34 reported 10 years of follow-up of a lifestyle weight-loss intervention, but both the lifestyle group and the comparison groups received weight loss counseling after a mean of 3.

  • Long-term effects of a lifestyle intervention on weight and cardiovascular risk factors in individuals with type 2 diabetes mellitus: four-year results of the Look AHEAD trial. Sforza E, Lugaresi E.

  • Visualizing real-time influenza virus infection, transmission and protection obje ili obese ferrets. In year 1, 5 ILI and 10 DSE participants had surgery, which increased by year 8 to a total of 76 and 84, respectively the latter values representing 3.

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Thus, sleep architecture changes can be obdse to be more strongly associated with OSA severity than body weight. Xavier Pi-Sunyer. Strohl, M. An exclusion criterion for initial participation in the Sleep AHEAD study was previous surgical or current medical treatment for OSA, although patients with a previous diagnosis of OSA who were not treated were eligible to participate. Participants who were receiving continuous positive airway pressure CPAP treatment for OSA during the follow-up period were asked not to use the treatment for 3 nights prior to experimental PSG recording. The researchers found that over the intervention period median, 9.

Registration is free. Apnea-hypopnea index AHI was the sum of the number of apneas and hypopneas per uli of sleep. It remains unclear if aspects of these education and support sessions may have accounted for the lack of clear between group effects on the various sleep architecture parameters. To our knowledge, this is the first report detailing the changes in nocturnal sleep duration and architecture in a long-term weight loss intervention with behavioral and diet recommendations. Rena R.

There were obje ili obese statistical differences in seroprotection or seroconversion rates between healthy weight and obese adults. In addition, all analyses were conducted with and without censoring weights of participants in both groups who underwent bariatric surgery. Try out PMC Labs and tell us what you think. Erik A.

Ped Infect Dis J. Healthy weight was defined as a BMI of References 1. The Jonckheere—Terpstra test was employed to assess associations between baseline covariates and the ordinal weight category. Support Center Support Center.

  • Risk Ratio vs Healthy Weight a.

  • In a study exploring the association between dietary patterns and sleep disordered breathing, Vasquez et al.

  • Mean losses, not censored for bariatric surgery, were 8. Consistent self-monitoring of weight: a key component of successful weight loss maintenance.

  • Decreased slow wave sleep increases risk of developing hypertension in elderly men.

  • Continue Reading.

Enjoying our content? Associations between short sleep duration and central obesity in women. Overnight nasal CPAP improves hypersomnolence in sleep apnea. Sleep architecture following a weight loss intervention in overweight and obese patients with obstructive sleep apnea and type 2 diabetes: relationship to apnea-hypopnea index. Effect of surgical weight loss on sleep architecture in adolescents with severe obesity. Open in a separate window.

Persistence of obstructive sleep apnea after obje ili obese weight loss. Xavier Pi-Sunyer. Measures included anthropometry, AHI, and sleep obesf baseline and year-1, year-2, and year-4 follow-ups. Table 2 shows the adjusted mean change from baseline in sleep duration, continuity, and architecture measures at year 1, year 2, and year 4 for ILI and DSE groups. Body weight measured in kg was assessed at the annual clinic visit by blind assessors, and was done within 1 week of PSG recordings.

As we have reported objje, compared with T cells from vaccinated healthy weight adults, T cells from influenza vaccinated obese adults are less activated when stimulated with vaccine strains of influenza 26 P values are adjusted for clinical site and the log of the baseline value for years 1, 4, and 8. Look AHEAD is the longest randomized controlled evaluation to date of an intensive lifestyle intervention for weight management.

  • The present analyses focused on the first 8 years of intervention, which all participants had the opportunity to complete before the trial was halted in September

  • Problem je bio pronaci dovoljno tanak kabel koji moze uci u utore.

  • As reported previously in ObesityILI participants achieved a mean loss of 8.

  • Anne B. Longer term effects of very low energy diet on obstructive sleep apnoea in cohort derived from randomised controlled trial: prospective observational follow-up study.

  • This is supported by the obese of a significant effect of year on stage 2 sleep, indicating that the expression of stage 2 sleep was above baseline values across the year 1, year 2, and year 4 follow-ups for both groups.

  • Associated Data Supplementary Materials 1.

Effect of surgical weight loss on sleep architecture obje ili obese adolescents with severe obesity. Open Next post in Prevention Close. FosterPh. Current findings further expose the important links that exist between obesity, T2D, sleep disordered breathing, and sleep, and indicate that reducing OSA severity can be associated with improvements in nocturnal sleep architecture. Thanks for visiting Rheumatology Advisor. This finding challenges the current standard for correlates of protection, suggesting use of antibody titers to determine vaccine effectiveness in an obese population may provide misleading information.

Long-term effect of weight loss on obstructive sleep apnea severity in obese patients with type 2 diabetes. Participants were randomized to an intensive lifestyle intervention ILI or a diabetes and support obesf DSE control group. HealthDay News — For overweight or obese individuals with diabetes mellitus DMintensive lifestyle intervention ILI does not increase overall fracture risk but correlates with increased risk of frailty fracture, according to a study published online in the Journal of Bone and Mineral Research. Association between sleep architecture and measures of body composition. Rena R. Daytime sleepiness and nasal continuous positive airway pressure therapy in obstructive sleep apnea syndrome patients: effects of chronic treatment and 1-night therapy withdrawal. Ann Intern Med.

Since that time, obesity has also been identified as a risk factor for seasonal and emerging influenza strains. Each family of comparisons, at each assessment time, was conducted using the Bonferonni correction. Within the ILI group, men and women achieved comparable weight losses over the 8 years, with mean differences between them ranging from 0. The opinions expressed in this paper are those of the authors and do not necessarily reflect the views of the I. Kumanyika SK. P values are adjusted for clinical site and baseline value for years 1, 4, and 8.

Author information Copyright and License information Disclaimer. Cheng et al. The mechanism for increased risk of influenza and ILI in the obese population may be due to poor T cell function. These include prevention and resolution of type 2 diabetes, 1112 reduction in blood pressure and lipids, 13 — 14 amelioration of non-alcoholic fatty liver disease, 15 and improvements in urinary incontinence and sexual dysfunction. Since that time, obesity has also been identified as a risk factor for seasonal and emerging influenza strains.

Appendix Authors: Thomas A. Jakicic, PhD; Robert W. These contrasting findings may be driven by differences in vaccine preparation live versus inactivatedor by differences between obese adults and children. Weight losses of African Americans were among the largest reported in the literature. Int J Obes Lond. The findings reported here demonstrate that, compared to vaccinated healthy weight adults, vaccinated obese adults were 2X more likely to develop influenza infection and ILI. Table 3 also presents the number of weeks in the past year that participants reported engaging in selected weight control behaviors.

Horton, MD; Van S. Green2 Jennifer Rebeles2 Erik A. During the — influenza season, the H3N2 vaccine strain obje ili obese a poor match for the circulating strain Participants Recruitment criteria for this study were adults 18 years of age and older receiving the seasonal trivalent inactivated influenza vaccine IIV3 for the years — and — The Indian Health Service I. Table 1 Demographics of all participants by study year and of participants with influenza or influenza like illness. Body weight data for participants who died during the 8-year trial were included in the analyses until censored at the time of death.

P values are adjusted for clinical site and baseline value for years 1, 4, and 8. Obje ili obese columns and demographic groupings, values with different superscripts i. At year 8, ILI participants lost 4. This finding may suggest that influenza infection rates in healthy weight and obese adults are similar, and therefore our findings are related to a failure of the vaccine to protect obese adults to the same extent as healthy weight adults. Corresponding values in DSE were 10, 45, and 84, respectively.

Relative to influenza incidence in vaccinated healthy weight adults, vaccinated obese adults had double the risk for laboratory confirmed influenza considered together with ILI estimated risk ratio obje ili obese. Footnotes A list of study authors and collaborators is shown in the appendix. There were no significant associations between weight and the odds of seroconversion for the multiple cut-off points considered. Previously, we 28 and others 34 — 36 have reported that HAI antibody titers 30 days post vaccination in obese adults or children are either slightly higher or no different from vaccinated healthy weight individuals.

However, statin use and diabetes was not independently associated with influenza or influenza-like illness. Participants were also instructed to contact the study nurse if they developed Obje ili obese. Guilford Press; New York: Previously, we 28 and others 34 — 36 have reported that HAI antibody titers 30 days post vaccination in obese adults or children are either slightly higher or no different from vaccinated healthy weight individuals. The four categories of weight change that these participants achieved at year 8 are presented in the same manner as in Figure 4 A. In addition, all analyses were conducted with and without censoring weights of participants in both groups who underwent bariatric surgery.

Effects of sleep fragmentation on appetite and related hormone oje over 24 h in healthy men. Table 3 Repeated measure mixed-model analysis with sleep measures over baseline, year 1, year 2, and year 4 as dependent variable. Recruitment criteria for this study were adults 18 years of age and older receiving the seasonal trivalent inactivated influenza vaccine IIV3 for the years and Measures included anthropometry, AHI, and sleep at baseline and year-1, year-2, and year-4 follow-ups. Repeated measure mixed-model analysis with sleep measures over baseline, year 1, year 2, and year 4 as dependent variable.

Participants who were receiving continuous positive airway pressure CPAP treatment for OSA during the follow-up period were asked not to use the treatment for 3 nights prior to obje ili obese PSG recording. Similar to what was observed in Sleep AHEAD, 19 longer-term follow-up assessments demonstrated that the intervention was associated with a sustained reduction in OSA severity, despite moderate weight regain over time. Registration is free. PSGs were scored manually using recommended criteria 22 at a single reading laboratory. To promote adherence to these calorie goals, participants were provided with meal replacement products. Support Center Support Center.

  • Participants were contacted weekly beginning with the first report of influenza activity in the community and contact was discontinued when influenza was no longer active. Visualizing real-time influenza virus infection, transmission and protection in ferrets.

  • Kuna has received research support from Philips Respironics.

  • A recent review on the association of obesity with vaccine responses points to a number of studies that demonstrate diminished vaccine-induced immune responses in both obese adults and children

  • Distinct associations between energy balance and the sleep characteristics slow wave sleep and rapid eye movement sleep.

Since then, a series of more structured, supervised lifestyle intervention studies have been conducted. ReboussinPh. Ohje loss is frequently recommended as a treatment for OSA symptoms in obese individuals, and reductions in OSA severity and concomitant improvements in nocturnal sleep quality have been observed in response to surgical 16 or diet-induced 17 weight reduction. In our study, participants in the DSE group were provided with education sessions focusing on diet, physical activity, and social support, which may have reduced some of the observed differences in sleep between the two groups.

Physical activity was assessed at baseline and years 1, 4, and 8 by the Paffenbarger Activity Questionnaire Obje ili obese26 which provides an estimate obesw weekly energy expenditure from moderate intensity physical activity e. Am J Epidemiol. J Immunol. In the — vaccine year, vaccination of participants started on September 15, and were completed on October 28, Indeed, we found no statistical differences in serological responses to vaccine between healthy weight and obese vaccinated adults.

Prijedlog je bio iskoristiti lakiranu zicu, ali ona je bila pretanka. Look AHEAD is a center randomized clinical trial investigating ojbe long-term effects of weight loss on cardiovascular morbidity and mortality in overweight and obese T2D patients. Participants who were receiving continuous positive airway pressure CPAP treatment for OSA during the follow-up period were asked not to use the treatment for 3 nights prior to experimental PSG recording. Enjoying our content? Throughout the 4-year follow-up period, none of the participants received surgical or dental treatment for OSA.

Motivational interviewing improves weight loss in women with type 2 diabetes. ILI participants achieved their maximum weight loss of 8. Supplementary Material 1 Click here to view. Institute of Medicine. There were no significant associations between weight and the odds of seroconversion for the multiple cut-off points considered. Laboratory confirmed influenza infection was determined from the medical records which reported a positive influenza specimen using the FDA cleared Cepheid Xpert Flu assay Cepheid, Sunnyvale, CA.

Prevalence of obesity, diabetes, and obesity-related health risk factors, Appendix Authors: Thomas Consequences obesity. Results Among obese, 9. DSE For pbese first 4 years, DSE participants were provided three 1-hour group meetings per year that discussed diet, physical activity, and social support, respectively. Despite the growing number of studies implicating obesity in poor responses to vaccination, and specifically influenza vaccination, a key question remains unanswered: in obesity and healthy weight, does vaccination offer the same protection from influenza and ILI? P values are adjusted for clinical site and baseline value for years 1, 4, and 8. Footnotes A list of study authors and collaborators is shown in the appendix.

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