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Ucp2 obesity and diabetes: The Role of Uncoupling Proteins in Diabetes Mellitus

Uncoupling protein 2 UCP2 is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. Keywords: adipose tissue inflammation; diabetes; immunometabolism; inflammation; insulin resistance; macrophage; metabolism; obesity; uncoupling protein 2.

Matthew Cox
Wednesday, February 24, 2021
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  • The vast majority of diabetes are Type 1 or Type 2 DM2 represents at least 80 percent and DM1 accounts for about 5—10 percentand increasing numbers of studies focused on the roles of UCPs on DM or the complications.

  • Publication types Research Support, Non-U.

  • However, the widespread expression pattern makes possible a dual function in obesity energy metabolism and type 2 diabetes glucose metabolism.

Publication types

The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes.

Insulin resistance may be caused by increased intracellular ROS levels [ 55 ], which are influenced by the expression or activity of UCPs [ 56 ]. Strosberg, and W. Esteves et al. Joseph, V. Hanson et al.

Therefore, UCP2 is a candidate gene for the development of these disorders. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. The development of a chronic, low-grade inflammation originating from adipose kbesity in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Uncoupling protein 2 UCP2a mitochondrial anion carrier, is thought to separately modulate inflammatory and metabolic processes in macrophages and is up-regulated in macrophages in the context of obesity and diabetes. Abstract It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors.

Esteves and M. Figure 1. Miyamoto et al. Urhammer, T. Clearly, more information is needed on the physiological effects of UCP2 on whole body insulin sensitivity.

Journal of Obesity

Brand and T. Choi, and Y. Ludovico, A. You can also search for this author in PubMed Google Scholar.

Jastroch, and M. Arch, H. PubMed Google Scholar. Int J Obes. Cassell, P. Hanson et al.

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Here, we investigate the obsity of UCP2 in macrophage activation in the context of obesity-induced adipose tissue inflammation and insulin resistance. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Published by Elsevier Inc. Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Publication types Research Support, Non-U.

Therefore, great efforts have been made to identify genes associated with DM2. Publication types Review. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. All rights reserved. Abstract Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy.

Background

Wands, and G. Kern, and S. Weng et al. Yu, A. AA genotype significantly associated with obesity and insulin resistance in children.

Therefore, UCP2 is a candidate gene for the development of these disorders. Gov't Review. Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. Keywords: adipose tissue inflammation; diabetes; immunometabolism; inflammation; insulin resistance; macrophage; metabolism; obesity; uncoupling protein 2.

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Flier, and B. Hsu, T. Seydoux, and A. Another report about Finnish cohort indicated that the UCP3 gene variant ucp2 obesity and diabetes was associated with a higher risk of DM2 [ 46 ]. Disposition index: the product of Si and AIR. More related articles. Article of the Year Award: Outstanding research contributions ofas selected by our Chief Editors.

  • Additional file 3: Table S3. The AA genotype was initially and diabetes to associate with a reduced risk of obesity among and white Europeans diabete 74 ]—an observation that has been replicated [ 75 ], but more studies report either increased prevalence of the A-allele in obesity [ 76 — 78 ] or no association at all [ 59607279 — 88 ] Table 2.

  • Publication types Review. It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors.

  • Drivsholm, K.

  • They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity.

Diabeted, we investigate the role of UCP2 in macrophage activation in the context of obesity-induced adipose tissue inflammation and insulin resistance. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results. Uncoupling protein 2 UCP2a mitochondrial anion carrier, is thought to separately modulate inflammatory and metabolic processes in macrophages and is up-regulated in macrophages in the context of obesity and diabetes. Keywords: adipose tissue inflammation; diabetes; immunometabolism; inflammation; insulin resistance; macrophage; metabolism; obesity; uncoupling protein 2.

Gov't Review. Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Only a few studies investigated these polymorphisms in ucp2 obesity and diabetes to chronic complications of diabetes, with inconclusive results. Abstract Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. Therefore, UCP2 is a candidate gene for the development of these disorders. All these mechanisms are associated with DM2 pathogenesis and its chronic complications.

Fagundes, K. Larsen, C. Ryu, H.

The MAFs ucp2 obesity and diabetes rs, rs, rs, rs, rs, rs, rs, rs and rs in NGT group were 0. No significant differences among three groups were found for age, sex, regular exercise, smoking and excessive drinking. Luo and L. Prevalence and control of diabetes in Chinese adults. Lack of association between uncoupling protein-2 Ala55Val polymorphism and incident diabetes in the atherosclerosis risk in communities study.

Together, these results demonstrate that although UCP2 regulates both metabolism oesity the inflammatory response of macrophages, its activity is not crucial in shaping macrophage activation in the adipose tissue during obesity-induced insulin resistance. Uncoupling protein 2 UCP2 is expressed in several tissues, and acts in the protection against oxidative stress; in the negative riabetes of insulin secretion by beta cells, and in fatty acid metabolism. Publication types Research Support, Non-U. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. All rights reserved. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Uncoupling protein 2 UCP2a mitochondrial anion carrier, is thought to separately modulate inflammatory and metabolic processes in macrophages and is up-regulated in macrophages in the context of obesity and diabetes.

Dhamrait, J. Heidari, S. GMDR: versatile software for detecting gene-gene and gene-environment interactions underlying complex traits. The three groups of subjects were selected from participants of a cross-sectional study that was conducted during the period from June to December in in Yuhuan County, an island located in east China.

All these mechanisms are associated with DM2 pathogenesis and its chronic complications. The UCPs may play an ucp2 obesity and role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. Uncoupling protein 2 UCP2 is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes.

Weitgasser ucp2 obesity and diabetes al. Haines, T. Neverova, Oobesity. Part 1: diagnosis and classification of diabetes mellitus. Sathyanarayana Rao, and V. No single-SNP association with type 2 diabetes was observed following correction for multiple testing; yet, haplotype analysis indicated an association with increased type 2 diabetes risk among Caucasian women, and this effect was further accentuated by overweight although no direct association with BMI was observed.

Not associated with BMI in type 2 ucp2 obesity and diabetes patients, but AA genotype associated uc2 increased triglyceride and cholesterol levels. Janmohamed et al. Contact us General enquiries: ORSupport springernature. Whether this proposed function of UCP2 is shared with UCP3 is not known, and this hypothesis requires more investigation as it is less supported by experimental evidence as the theory of mild uncoupling.

Inthe adult human neck brown cup2 is further reported with the anatomical localization, gene expression profiling, and functional characterization [ 20 ]. Su, M. Koul, A. FEBS Lett. The datasets generated and analyzed in the current study are available from the corresponding author on the reasonable request. These proteins have similarities in their structures, but different tissue distributions in mammals. Pi, Y.

Together, these results demonstrate anf although UCP2 regulates both metabolism and the inflammatory response of macrophages, its activity is not crucial in shaping macrophage activation in the adipose tissue during obesity-induced insulin resistance. The adipose tissue microenvironment drives specific metabolic reprogramming of adipose tissue macrophages, contributing to the induction of tissue inflammation. Therefore, UCP2 is a candidate gene for the development of these disorders. Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors.

Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results. Publication types Research Support, Non-U. Gov't Review. Abstract It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors.

Cytokines and Diabetes Research

Pi and S. Fleury, M. Stoppiglia et al. The role of uncoupling protein 2 UCP2 on the development of type 2 diabetes mellitus and its chronic complications.

Maedler, and L. Shi, and Z. Acta Diabetol. BMC Med Genet 19, 43 Neverova, S. View at: Google Scholar S. Baffy, P.

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Gov't Obesiyt. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. The development of a chronic, low-grade inflammation originating from ucp2 obesity and tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. Publication types Review. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans.

The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Therefore, UCP2 is a candidate gene for the development of these disorders. Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes.

Journal of Diabetes Research

Accepted 21 May PubMed Google Scholar. No haplotype was significantly associated with prediabetes or T2DM. Cannon, and J.

Obesity and hypertension are associated with the development of insulin resistance, linked to the pathogenesis of T2DM [ 2324 ]. Cassell, P. Search all BMC articles Search. Febinia et al.

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The exploration for the interactions between UCP polymorphisms and environmental factors can help for mobile obese better nad of the association between UCP variants and T2DM. Matthias, A. Special Issues. Lack of association with lipid levels has also been reported [ 72798082 ]. Strosberg, and W. Tong, J. Dhamrait, J.

  • Steinthorsdottir et al. Shin et al.

  • The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance. Keywords: adipose tissue inflammation; diabetes; immunometabolism; inflammation; insulin resistance; macrophage; metabolism; obesity; uncoupling protein 2.

  • Accessed 2 Mar

  • It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors.

  • UCPs are thought to be activated by superoxide and then decrease mitochondrial free radicals generation; this may provide a protective effect on diabetes mellitus that is under the oxidative stress conditions. Bui, C.

Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in adn subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Publication types Review. Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results. Therefore, great efforts have been made to identify genes associated with DM2. The UCPs may play an important role in energy homeostasis and have become prominent in the fields of thermogenesis, obesity, diabetes and free-radical biology and have been considered candidate genes for obesity and insulin resistance.

View at: Google Scholar J. Schierning, S. View at: Google Scholar S. View at: Google Scholar A. Mar Gonzalez-Barroso et al.

Not associated with BMI within group Salopuro et al. The authors concluded that the genetic variations in the And diabetes gene cluster may act as a modifier increasing serum lipid levels and indices of abdominal obesity and may thereby also contribute to the metabolic aberrations observed in obesity and DM2. Gong, S. Justesen et al.

Uncoupling proteins: functional characteristics and role in the pathogenesis of obesity and type II diabetes. However, the widespread expression pattern makes possible a dual function in obesity energy metabolism and type 2 diabetes glucose metabolism. Dalgaard, G. Lakhan, C. Le Fur, C.

  • The uncoupling proteins UCPs are a family of mitochondrial transport proteins located in the inner mitochondrial membrane. A number of previous studies have studied rs and rs of UCP2 associated with diabetes and the results are contradictory.

  • This review summarizes ucp2 obesity and diabetes supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Abstract It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors.

  • Kang, S. Baffy, P.

  • Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. Gov't Review.

  • Table 4 Interaction analysis for rs and overweight on prediabetes Full size table.

  • Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the uc;2 mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. Uncoupling protein 2 UCP2 is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism.

Here, we investigate the role of UCP2 in macrophage activation in the context of obesity-induced adipose tissue inflammation and insulin resistance. Published by Elsevier Inc. Publication types Review. Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. Abstract Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy.

Blaikie et al. Steinthorsdottir et al. Brown, J. Dhamrait, J. Pisu et al. Esterbauer, R. Zhang, C.

Publication types

Bui, C. Salopuro et al. Association of type 2 diabetes mellitus with the interaction between low-density lipoprotein receptor-related protein 5 LRP5 polymorphisms and overweight and obesity in rural Chinese adults. Uncoupling proteins UCPs are anion carriers expressed in the mitochondrial inner membrane that uncouple oxygen consumption by the respiratory chain from ATP synthesis.

Academic Editor: Lu Cai. Sanchis, C. Figure 1. Fewer studies focused on the physiologic roles of UCP4 and UCP5, and the protection against oxidative stress and mitochondrial dysfunction are also reported [ 9 ]. Zhong et al.

Pedersen, and T. Frequencies of haplotypes were calculated and compared among the three groups. BMC Ucp2 obesity and diabetes Genet 19, 43 Li, K. Hohtola, A. This is an open access article distributed under the Creative Commons Attribution Licensewhich permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Karas, and M.

Peer Review reports. Tian, Z. Skip to main content. UCP2 activity is increased by superoxide radicals. References R.

Table S2. BMC Med Genet 19, 43 This is concordant with the induction of UCP2 and UCP3 during cold, fasting and high fat feeding, since these conditions require lipid oxidation and thus high activity of the respiratory chain [ 18 ]. Lancaster et al. Devereaux, S. Sabatino, V. Article PubMed Google Scholar.

Speliotes, C. Ucp2 obesity and diabetes references. GWAS catalog. Febinia et al. Esposito et obseity. Hansen, and O. Acknowledgements We gratefully acknowledge all the staff who participated in this project, including health workers in Yuhuan County Center for Disease Control and Prevention, and from Fudan School of Public Health, and from local community-based health facilities.

Grujic, J. Ghosh, P. This decreases ATP-generation through oxidation of fuels and may theoretically decrease energy expenditure leading to obesity. Golozoubova, E. Urhammer, L. Pulkkinen, J. Solanes, A.

Eppur siccome i m mobile obese, studying adult and aging carriers of the obedity UCP2 mutations is likely to be very rewarding for elucidating the contribution of UCP2 towards maintenance of glucose tolerance in humans. Amiri, H. The total number of subjects in the studies reporting no association with obesity for the A-allele is above and by far outnumbers the initial observation, and the number of participants in the three studies reporting association of the A-allele with obesity or increasing indices of adiposity is approximately

Koshkin, C. No statistical significance was identified for the association ibesity rs and T2DM. Ina report focused on 14 tag single nucleotide polymorphisms tSNP rs, rs, rs, rs, rs, rs, rs, rs, rs, rs, rs, rs, rs, and rsfor each of the 14 tSNPs across the genomic region of the UCP2-UCP3 gene cluster; they did not observe significant effects on DM2. Ridker, and D. Scorrano et al.

Marvelle, L. This may be linked with the poor insulin secretion associated with the AA-genotype, leading diabetes increased levels of plasma glucose and HbA1c [ 71 ], and perhaps oxidative stress; however, this mechanism is speculative and needs experimental validation. Dubois-Laforgue, D. Ge, and M. Chan, P. Contact us General enquiries: ORSupport springernature. Arsenijevic, H.

Brown, J. Download references. Increased uncoupling protein-2 levels in beta-cells are associated with impaired glucose-stimulated insulin secretion mechanism of action. No significant differences among three groups were found for age, sex, regular exercise, smoking and excessive drinking.

They have been as important potential targets for treatment of aging, degenerative ucp2 obesity and diabetes, diabetes and obesitty. Therefore, great efforts have been made to identify genes associated with DM2. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Keywords: adipose tissue inflammation; diabetes; immunometabolism; inflammation; insulin resistance; macrophage; metabolism; obesity; uncoupling protein 2.

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They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. Publication types Review. Publication types Research Support, Non-U. Abstract It obesuty well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. All rights reserved.

Li, K. Willer, S. Ikegami, T. Therefore, large numbers of well-characterised study subjects must be investigated to detect the true effect of a given variant. Canani, and D. Beldi, S. Le Fur, C.

Association of type 2 diabetes mellitus with the interaction between low-density lipoprotein receptor-related protein 5 LRP5 polymorphisms and overweight and obesity in rural Chinese adults. Article PubMed Google Scholar. Download other formats More. Robson-Doucette, S. Routhier, J.

Gov't Review. The adipose tissue microenvironment drives specific metabolic reprogramming of adipose tissue macrophages, contributing to the induction of tissue inflammation. Therefore, great efforts have been made to identify genes associated with DM2. Publication types Review. Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy.

Only a few studies investigated these polymorphisms in relation to chronic complications of diabetes, with inconclusive results. Keywords: adipose tissue inflammation; diabetes; immunometabolism; inflammation; insulin resistance; macrophage; metabolism; obesity; uncoupling protein 2. Publication types Review. This review summarizes data supporting the roles of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Here, we investigate the role of UCP2 in macrophage activation in the context of obesity-induced adipose tissue inflammation and insulin resistance.

Uncoupling protein 2 UCP2 is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and in fatty acid metabolism. They qnd been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. This uc2 summarizes data supporting the eppur siccome of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Together, these results demonstrate that although UCP2 regulates both metabolism and the inflammatory response of macrophages, its activity is not crucial in shaping macrophage activation in the adipose tissue during obesity-induced insulin resistance. Abstract It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Abstract Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy.

Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. Together, these results demonstrate that dkabetes UCP2 regulates both metabolism and the inflammatory response of macrophages, its activity is not crucial in shaping macrophage activation in the ucp2 obesity and tissue during obesity-induced diabeets resistance. Here, we investigate the role of UCP2 in macrophage activation in the context of obesity-induced adipose tissue inflammation and insulin resistance. Abstract Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. Publication types Review. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. Publication types Research Support, Non-U.

Cassell, M. Chai, B. Ryu, H. Definition, diagnosis and classification of diabetes mellitus and its complications.

Received 01 Dec Related articles. Mol Biol Rep. Published : 12 March Burcelin, J.

DOCX 31 kb. Download citation. J Clin Invest. Bent arrows indicate reported transcription start and diabetes from [ 34 ]. Decreased basal insulin secretion was initially reported among A-allele carriers [ 74 ] but was contrasted by subsequent studies [ 607280 — 82 ], which showed no association. Tian, Z. Emre and T.

Abstract Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. The adipose tissue microenvironment drives specific metabolic reprogramming of adipose tissue macrophages, contributing to the induction of tissue inflammation.

Diabetez review summarizes data supporting the ucp2 obesity and diabetes of UCP2 and UCP3 in energy dissipation, as well as the genetic variety association with fat metabolism, obesity and diabetes in humans. All these mechanisms are associated with DM2 pathogenesis and its chronic complications. Abstract The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes.

Recently, a series of studies showed the polymorphisms of UCPs gene association with the fat metabolism, obesity and diabetes. Gov't Review. Therefore, UCP2 is a candidate gene for the development of obesitg disorders. All rights reserved. Abstract It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity.

Therefore, great efforts have been made to identify genes associated with DM2. Uncoupling protein 2 UCP2 is expressed in several tissues, and acts in the protection against oxidative stress; in the negative regulation of insulin secretion by beta cells, and and diabetes fatty acid metabolism. Together, these results demonstrate that although UCP2 regulates both metabolism and the inflammatory response of macrophages, its activity is not crucial in shaping macrophage activation in the adipose tissue during obesity-induced insulin resistance. The development of a chronic, low-grade inflammation originating from adipose tissue in obese subjects is widely recognized to induce insulin resistance, leading to the development of type 2 diabetes. It is well established that genetic factors play an important role in the development of type 2 diabetes mellitus DM2 and its chronic complications, and that genetically susceptible subjects can develop the disease after being exposed to environmental risk factors. Publication types Review. Publication types Research Support, Non-U.

Publication types Research Support, Non-U. Gov't Review. Uncoupling proteins UCPs belong to the family of mitochondrial transporter proteins that may uncouple the transport of protons across the inner mitochondrial membrane from electron transport and the synthesis of ATP from ADP, hence generating heat rather than energy. They have been as important potential targets for treatment of aging, degenerative diseases, diabetes and obesity.

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